Senior/Principal Scientist in Computational Biology

About Cellular IntelligenceCellular Intelligence, previously known as Somite AI, is an innovative venture-backed firm striving to redefine the realm of stem cell biology. We are on a mission to develop AI foundation models that will revolutionize human stem cell applications and promote scalable novel cell therapies.Our comprehensive approach involves genera…

About AbiologicsAbiologics is a pioneering company under Flagship Pioneering, dedicated to innovating in the field of synthetic biology through the development of Synteins™—a revolutionary category of fully synthetic proteins crafted from entirely artificial building blocks, including D-amino acids and non-canonical residues. Synteins are engineered to overcome the constraints of conventional biologics, offering enhanced oral stability, immune evasion, and metabolic durability, all while being fully programmable by design.Utilizing a cutting-edge AI-enabled discovery platform, Abiologics merges generative design, automated synthesis, and rapid experimental screening to facilitate iterative optimization at scale.

Asimov builds tools for designing living systems, combining mammalian synthetic biology with software to support next-generation therapeutics. The Biologics Cell Line Development team in Boston, MA, is growing, and we're seeking a Principal Scientist to help lead our efforts in CHO-based cell line development for biologic therapeutics moving into clinical trials. Role Overview This Principal Scientist position calls for a scientific leader ready to manage a team and drive innovation in cell line development. The role involves designing and executing complex experiments, improving expression systems, and collaborating closely with teams across synthetic biology, modeling, process development, and analytics. The work directly supports Asimov’s mission to advance biological engineering in a startup environment. What You Will Do Oversee CHO cell line development, including transfection, cloning, characterization, and cell banking using advanced technologies. Develop new genetic components, engineer host cell lines, and refine development processes to improve biologics production. Stay current with emerging practices in biologics cell line development and manufacturing, applying new strategies to ongoing projects. Represent the cell line development group on cross-functional projects, making key decisions and communicating progress and plans. Contribute to the scientific community by presenting at conferences, filing patents, and publishing peer-reviewed research. Lead and mentor a team of at least three scientists, providing technical guidance and supporting their career growth. Qualifications At least 8 years of experience in CHO-based cell line development, with a focus on IgG and bispecific expression in an industrial setting. Demonstrated success in creating innovative solutions and experimental approaches in cell line development. Experience managing and developing scientific teams. Strong communication skills for effective work across multidisciplinary groups.

Asimov is seeking a highly skilled and experienced Senior Scientist/Principal Scientist in Biologics Cell Line Development to join our innovative team in Boston, MA. In this pivotal role, you will lead the development of high-yield mammalian cell lines for the production of biologics. You will collaborate closely with cross-functional teams to optimize production processes and ensure the successful translation of cell line development from research to clinical applications.

About AbiologicsAbiologics is a pioneering biotechnology company at the forefront of developing Synteins™—a revolutionary class of fully synthetic proteins crafted from artificial building blocks like D-amino acids and non-canonical residues. Our Synteins are engineered to overcome the limitations of traditional biologics, offering enhanced oral stability, immune evasion, and metabolic durability—all while being fully programmable by design.Utilizing an advanced AI-enabled discovery platform, Abiologics seamlessly integrates generative design, automated synthesis, and rapid experimental screening to facilitate large-scale iterative optimization.Position SummaryWe are on the lookout for a talented Protein Design Scientist to become a key member of our Computational Protein Design team. In this interdisciplinary role, you will spearhead structure-based design and optimization of synthetic proteins, operating at the intersection of computational design, structural biology, and protein engineering.

Join our innovative team at Cellular Intelligence as a Research Associate/Associate Scientist specializing in iPSC Biology. In this role, you will contribute to pioneering research in induced pluripotent stem cells (iPSCs), collaborating with a dedicated group of scientists focused on advancing cellular therapies and regenerative medicine. You will engage in experimental design, data analysis, and the development of cutting-edge methodologies.

Axon Enterprise, Inc. develops devices and cloud-based software focused on public safety and justice. The company’s teams value collaboration, open communication, and diversity, aiming to create meaningful change while supporting employee growth and ownership. Role overview The Principal Data Scientist will join the Office of the Chief Accounting Officer in Boston. This position blends technical expertise with a strong understanding of finance and accounting. The main goal is to ensure Axon’s AI developers, process owners, decision-makers, and auditors have access to reliable, well-governed data that meets audit requirements. Main responsibilities Design and build data analytics tools and pipelines, dedicating about half of the workload to hands-on development. Apply AI to advance projects such as M&A integration, ERP rollouts, upstream data remediation, and SOX compliance. Work closely with teams in Controllership, Finance Operations, FP&A, Internal Audit, and Technology to support AI, automation, and audit readiness. Incorporate AI-driven development tools into daily tasks to improve productivity and outcomes. Location This position is based in Boston, Massachusetts, United States.

CarGurus, a leading online automotive marketplace, is seeking a Principal Data Scientist to join our innovative team in Boston, Massachusetts. As a Principal Data Scientist, you will leverage your expertise in data analysis, machine learning, and statistical modeling to drive insights that enhance our product offerings and improve user experiences. You will play a crucial role in shaping our data strategy and leading complex projects that impact the entire organization.

About Us: Axiomatic AI is pioneering a new generation of AI systems that apply the scientific method rigorously. By integrating deep learning with formal logic and physics-based modeling, we develop verifiable and interpretable AI systems that enhance and assist human researchers within critical scientific and engineering processes. Our Mission, 30×30: We are committed to achieving a 30× enhancement in the speed, accessibility, and affordability of semiconductor and photonic hardware development by the year 2030. We envision transforming hardware design and simulation across these sectors and are assembling a team of passionate professionals to translate these advancements from research into commercial products. Position Overview: As an AI Research Scientist specializing in photonic and neuromorphic computing, you will be instrumental in crafting AI algorithms and architectures, as well as simulation and optimization frameworks tailored for innovative, non-traditional computing platforms. You will help develop algorithms, digital twins, and training methods that connect AI, physics, and hardware-aware system design within Axiomatic's next-generation computational science tools. This position is part of Axiomatic's long-term research and product strategy, involving collaboration across various projects and initiatives, and working closely with AI researchers, physicists, and software engineers to translate cutting-edge concepts into scalable, impactful solutions. Your Mission: Simulation and Digital Twins: Create simulation and digital-twin tools that effectively model physical effects such as nonlinearities, noise, and precision limits, facilitating hardware-aware algorithm development. Co-Design and Collaboration: Collaborate with internal AI, software, and hardware teams to ensure cohesive alignment between algorithms, system constraints, and overarching platform objectives, including the automation of scientific workflows. Algorithm and System Design: Architect and prototype machine-learning frameworks and physics-aware optimization workflows for neuromorphic systems, examining efficient mappings of AI models onto emerging hardware substrates. Research, Benchmarking, and Reporting: Assess system-level performance trade-offs, conduct benchmarking studies, document findings, and contribute to technical decision-making across Axiomatic’s R&D portfolio.

Join Formation Bio as a Principal Data Scientist, where you will play a pivotal role in shaping our data-driven strategies. We are seeking a highly skilled and innovative data scientist to lead complex projects and drive actionable insights from our data.In this position, you will collaborate with cross-functional teams, leveraging your expertise in statistical analysis, machine learning, and data visualization to inform decision-making and improve our products. Your contributions will directly impact our mission to harness data for groundbreaking advancements in biotechnology.

Inductive Bio is a pioneering AI medicinal chemistry partner dedicated to revolutionizing drug discovery. We create innovative virtual labs that empower drug discovery teams to make informed decisions more efficiently throughout the entire DMTA cycle. Our advanced platform features Beacon-1 ADMET prediction models, human dose projection tools, and Indy, an AI-driven medicinal chemistry assistant. In collaboration with Enamine, we provide library synthesis and direct-to-dose testing, seamlessly bridging the gap between computational design and experimental validation. Together, we fuel numerous small molecule and beyond-rule-of-five initiatives for our biotech and pharmaceutical partners.Beacon-1 has consistently excelled, securing 1st place in both the 2025 Polaris and 2026 OpenADMET-ExpansionRx blind competitions, surpassing industry giants like Merck & Co and NVIDIA, as well as EMD Serono. Our efforts have garnered $30M in funding from notable investors such as Obvious Ventures, a16z Bio + Health, and Lux Capital, in addition to being awarded $21M from the ARPA-H CATALYST program to advance next-generation toxicity models.The RoleWe are in search of an experienced computational or medicinal chemist to join our dynamic Product Science team as a Product Scientist. In this pivotal role, you will be the primary scientific liaison for partner projects, leveraging your expertise in medicinal chemistry, computational chemistry, and DMPK to tackle complex molecular optimization challenges with an emphasis on dose-centric solutions. You will engage with a diverse array of small molecule modalities, therapeutic areas, and modeling obstacles.As a thought leader in the evolution of Inductive's platform, you will contribute to the enhancement of our predictive models and dose projection tools, as well as Indy, our AI medicinal chemistry assistant, drawing from your own experiences and insights gained from real-world partner programs. We seek an individual whose instincts regarding small molecule optimization are honed through extensive hands-on experience, and who is eager to utilize these instincts to shape products that empower drug discovery teams.Your Responsibilities:Partner-Facing ScienceCultivate and manage the scientific relationships with partner project teams across various modalities, including reversible and covalent small molecules, macrocycles, molecular glues, and heterobifunctionals.Organize and clarify complex program data. Analyze structure-activity relationships (SAR), discern the insights provided by the data, and proactively address inconsistencies before they lead to detrimental decisions.Steer medicinal chemistry strategies: determine what to synthesize, what to test, how to prioritize compounds for further development, and where to allocate synthetic resources. Identify potential liabilities early in the process and assist partners in constructing risk mitigation plans.

IonQ is looking for a Senior Research Scientist with expertise in Fabrication to help drive progress in quantum computing hardware. This position is based in Boston, Massachusetts. Role overview This role centers on leading research projects focused on developing new fabrication methods for quantum hardware. The Senior Research Scientist will work closely with colleagues from various disciplines to design, test, and refine fabrication processes that improve the performance and reliability of IonQ’s quantum systems. What you will do Lead research initiatives to create and advance fabrication techniques for quantum computing hardware Collaborate with cross-functional teams to design, implement, and optimize fabrication processes Contribute to the enhancement of IonQ’s quantum hardware capabilities through innovative research Requirements Strong background in fabrication, ideally with experience relevant to quantum hardware Ability to lead research projects and work effectively with multidisciplinary teams Motivation to develop and improve fabrication processes for advanced technology

At IonQ, we are pioneering the development of the world's most advanced full-stack quantum computer utilizing trapped-ion technology. Our mission is to transcend the limitations of classical physics and current supercomputing capabilities, ushering in a transformative era of computing. The potential of quantum computing to enhance every aspect of human life is immense, and IonQ's innovations are set to revolutionize fields including medicine, materials science, finance, artificial intelligence, machine learning, cryptography, and beyond. Join us at the forefront of this technological evolution.We are seeking a Senior Research Scientist specializing in quantum memory development. In this pivotal role, you will spearhead a cross-functional team dedicated to advancing IonQ's mission to construct the preeminent quantum computers capable of tackling the world's most intricate challenges.Your work will involve groundbreaking research in quantum memories tailored for extensive quantum networks and modular quantum computing architectures. Collaborating with a prestigious team of scientists and engineers, you will develop systems designed for rapid processing and storage of quantum information derived from photons, ultimately leading to the creation of scalable quantum computing solutions. Your contributions will range from innovative system design to operationalizing and expanding quantum memory systems that will serve as the foundation for the largest quantum computers globally.

IonQ is at the forefront of quantum computing, pioneering the development of the world's most advanced full-stack quantum computer using trapped-ion technology. Our work transcends the boundaries of classical physics and supercomputing, ushering in a transformative era for computing. Quantum computing holds the promise of significantly enhancing various sectors, including medicine, materials science, finance, artificial intelligence, machine learning, cryptography, and beyond. Join us as we redefine industries with our cutting-edge quantum solutions.We are seeking a talented and driven Lead Microwave Research Scientist to join our dynamic team. In this role, you will collaborate with a multidisciplinary team dedicated to advancing IonQ's mission of constructing the most effective quantum computers capable of addressing the globe's most intricate challenges.As a Lead Microwave Research Scientist, you will be responsible for:Collaborating with architecture teams to translate system-level specifications into detailed component-level requirements and design guidelines.Designing microwave circuits while considering performance targets, fabrication capabilities, and interactions with other components.Fabricating and testing prototype devices.Managing partnerships with external vendors to enhance fabrication and testing processes at scale.Working alongside internal testing and measurement teams to verify that devices fulfill specified performance criteria.

Join Motional's cutting-edge team at our global headquarters located at 100 Northern Avenue in Boston, MA. Situated in the lively Seaport district, our office boasts stunning views of Boston Harbor and is conveniently close to major transit lines, a variety of restaurants, and popular attractions.Mission Overview:At Motional, our CORE team is at the forefront of developing our vehicle's Compute and Onboard Runtime Environment. We are dedicated to creating a leading AI compute platform for autonomous vehicles, executing the software and neural networks crucial for vehicle autonomy.The Next-Gen Technologies team, a key part of CORE, operates at the intersection of software engineering, machine learning, sensors, and hardware compute platforms to advance Motional's onboard vehicle architecture. If you are a passionate software engineer excited about embedded AI hardware and software systems, we would love to connect with you!Your Role:As a Senior Engineer on the Next-Gen Technologies team, you will play a vital role in enhancing the compute performance of our autonomous driving systems, contributing to the entire development lifecycle from ideation to proofs-of-concept to production.Your Responsibilities:Specialize in ML model deployment, integration of multiple ML models, and optimization on embedded compute platforms.Deep dive into the complete ML software stack, analyzing workload performance across various hardware processors, optimizing ML models, and enhancing ML software to continuously improve our stack with efficient approaches.Design, develop, test, integrate, and optimize software tools on diverse ML compute architectures.Collaborate with experts in perception, prediction, and other autonomous driving areas to enable algorithms on GPU, NPU, and other ML accelerator architectures.Optimize GPU/NPU resource utilization and manage sharing across multiple programs on the same system.Lead design initiatives to assess system needs and enhance our ML software stack accordingly.Provide technical guidance to peers and management.

Join Formlabs as a Senior Materials Scientist and play a crucial role in advancing our innovative 3D printing technologies. You will be instrumental in developing new materials and enhancing existing formulations to meet the diverse needs of our users. Collaborate with cross-functional teams to drive product development and ensure the highest standards of quality. Your expertise will help shape the future of additive manufacturing.

Cellular Intelligence (CI) is a pioneering AI-driven TechBio firm dedicated to constructing a universal foundation model of cell signaling. Our goal is to comprehend, forecast, and ultimately manipulate cellular behavior, thereby revolutionizing biology from a trial-and-error approach into a precise engineering discipline. With a full-stack methodology, we produce perturbation data at over 1,000 times the efficacy of traditional methods, capturing millions of time-resolved treatment combinations in each experiment. Our large-scale models are designed to generalize across various contexts, facilitating rational protocol design for regenerative medicine, specific drug effect prediction, and systematic disease modeling. The founding team includes notable AI entrepreneur Dr. Micha Breakstone, former Head of the Fundamental AI Group at MIT, and four esteemed professors from Harvard Medical School and the University of Washington, including the Chair of Genetics at Harvard, collectively holding five National Academy memberships. Based in Boston, CI has successfully raised over $60 million from investors such as Khosla Ventures, CZI, SciFi VC, and AMD Ventures, and is rapidly expanding its exceptional team.Core Values of Cellular IntelligenceAccountability - We show up fully accountable, committed, and ready to do whatever it takes.Urgency - We act swiftly, decisively, and proactively.Collaboration - We support each other through teamwork, helpfulness, and empathy.

COMPANY DESCRIPTION Abiologics, Inc. is an innovative, privately held biotechnology company dedicated to transforming biology through advanced therapeutic modalities. We are leading the charge in developing Synteins™, a groundbreaking class of macromolecular medicines propelled by cutting-edge synthetic and computational technologies. We are on the lookout for outstanding scientists who are fervent about pioneering therapeutic modality innovations within the biotechnology landscape. Founded within Flagship Pioneering’s venture creation engine, Abiologics has its roots alongside remarkable companies such as Moderna Therapeutics (NASDAQ: MRNA) and Generate Biomedicines. Since its inception in 2000, Flagship has nurtured over 100 scientific ventures, producing more than 500 patents and facilitating over 50 clinical trials for novel therapeutic agents. THE ROLE We invite applications for an experienced and driven Senior Scientist in Medicinal Chemistry, with a specialization in miniprotein and peptide drugs. The ideal candidate will be instrumental in the design, synthesis, and optimization of innovative miniprotein therapeutics known as Synteins™. This role provides a distinctive opportunity to guide a new drug modality from early-stage research all the way through clinical development. KEY RESPONSIBILITIES Independently plan, execute, interpret, and enhance Syntein structure-activity campaigns through hands-on laboratory engagement. Utilize modern peptide chemistry and conjugation techniques to expedite the optimization of miniprotein drug development. Collaborate with interdisciplinary teams, including computational chemistry, biology, and pharmacology, to ensure project success. Champion innovation at the bench-side, ensuring a seamless transition from concept to execution. Mentor and lead junior scientists, promoting a collaborative and dynamic laboratory environment. Contribute to patent applications and scientific publications, highlighting laboratory advancements.

Join the innovative team at Cellular Intelligence as a Research Associate in Molecular Biology. In this pivotal role, you will contribute to groundbreaking research and development initiatives that push the boundaries of molecular biology.As a Research Associate, you will perform essential laboratory experiments, analyze data, and collaborate closely with senior researchers to advance our understanding of cellular processes.

IonQ is at the forefront of the quantum computing revolution, pioneering the development of the world’s most advanced full-stack quantum computer utilizing trapped-ion technology. Our mission transcends classical physics and supercomputing, aiming to usher in a new era of computing that has the potential to positively transform every facet of human society. Industries such as medicine, materials science, finance, artificial intelligence, machine learning, and cryptography will be redefined by IonQ’s groundbreaking technology.As a Senior Atomic Physicist, you will play a crucial role in the development of optical signal chains for long-range quantum networks and modular quantum computing. Collaborating with a distinguished team of scientists and engineers, you will contribute to the creation of systems designed to efficiently process and store quantum information from photons, which are essential for constructing scalable quantum computing architectures. Your work will encompass everything from the innovative design of systems to the operational scaling of optical signal chains that will serve as the backbone for the world’s largest quantum computers.