Senior Scientist, Discovery Pharmacology

Altos Labs focuses on revitalizing cellular health and resilience to address disease, injury, and lifelong disabilities. The company emphasizes collaboration and inclusion, aiming to value every perspective within its team. Altos Labs has received recognition among leading biotech companies and is featured in Forbes 2026 Best Startups in America. Role overvi…

At Intrinsic Safety, we're leveraging innovative technologies to tackle some of the most challenging issues of our digital era using safe and effective AI solutions. Your contributions will play a pivotal role in assisting fraud prevention and Trust & Safety teams, enabling them to concentrate on impactful tasks rather than repetitive manual reviews. We're experiencing rapid growth, partnering with some of the largest and most dynamic social media and online service platforms.We are on the lookout for an exceptional Technical Account Manager (TAM) to join our core Customer Success team. In this role, you will be crucial in ensuring our customers—particularly our enterprise clients—derive maximum value from Intrinsic Safety by providing expert technical support and guidance. You will act as the essential link between our advanced AI platform and our customers' technical teams, fostering deep platform adoption, troubleshooting complex issues, and facilitating their long-term success. This is a unique opportunity to contribute to our mission by transforming intricate technical challenges into practical solutions that effectively combat fraud and abuse.This role requires in-person attendance at our San Francisco office.Your ResponsibilitiesPost-Integration Technical Partnership: Serve as the main technical liaison for our enterprise customers post-deployment. Gain a thorough understanding of their unique technical environments and data flows as they interact with the Intrinsic Safety platform.Drive Ongoing Technical Adoption & Optimization: Assist customers in navigating advanced platform features and configurations to ensure they maximize the benefits of Intrinsic Safety’s offerings.Build Scalable Technical Resources: Develop and enhance our knowledge base, technical documentation, and best practice guides to empower both customers and the Customer Success team.Strategic Technical Troubleshooting & Resolution: Identify and resolve sophisticated technical challenges that arise after implementation, working closely with engineering and product teams to deliver scalable solutions.Product Evolution: Act as a key contributor to the continual improvement of our product offerings.

Charter:Join us as a pioneering member of a team dedicated to developing groundbreaking AI technologies aimed at replacing traditional lab and animal toxicity experiments with advanced AI models.About Axiom:At Axiom, we are revolutionizing preclinical safety through the creation of AI models that predict human toxicity more effectively than conventional animal tests and outdated in vitro assays. We seek an innovative computational biologist who excels at the convergence of high-dimensional data analysis, cellular biology, and machine learning. Collaborating with a premier team of scientists and engineers, you will develop predictive models based on imaging and functional biochemical data, providing insights that influence real-world drug development. This role is ideal for those passionate about transforming biological signals into actionable insights, designing innovative assays, and partnering with leading pharmaceutical companies to accelerate safer and more human-centric drug discovery.What We Seek:We are eager to hire individuals who inspire us and challenge us to excel. You will elevate the entire team with your vibrant energy and profound sense of purpose. We look for candidates who possess a refined sense of priority, a keen eye for necessity, and an unwavering commitment to action. A deep-seated curiosity about all aspects of Axiom and an ambitious drive should fuel your enthusiasm for our mission. You must be a technically proficient and dedicated expert in your field, driven by the challenge of tackling complex scientific problems and contributing to a generational company.Your Responsibilities:Lead the exploration and analysis of extensive multimodal toxicity datasets.Convert complex, high-dimensional biological data into clear, actionable insights by identifying key signals.Discover novel biological signals that distinguish safe drugs from toxic ones.Perform comprehensive error analyses on machine learning models to clarify the biological insights captured by algorithms.Develop innovative algorithms that bridge computation and biology to model unexplored biological mechanisms.Examine diverse biological systems including liver, heart, kidney, and immune tissues to enhance drug safety assessments.

About UsAt Latent Labs, we are at the forefront of developing advanced models that delve into the core principles of biology. Our ambitious pursuits are driven by curiosity and a steadfast commitment to scientific excellence. The team behind Latent Labs previously co-developed DeepMind's Nobel Prize-winning AlphaFold, pioneered latent diffusion technology, and created groundbreaking laboratory data management systems alongside high-throughput protein screening platforms. By joining us, you will collaborate with some of the brightest minds in the fields of generative AI and biology.We believe in fostering interdisciplinary collaboration, continuous learning, and teamwork. Our team offsites are designed to cultivate a culture of trust between our London and San Francisco locations.We're on the lookout for innovators who are passionate about solving complex challenges and making a positive global impact. Be part of our monumental mission!Your RoleWe are excited to invite a Research Scientist to join our team, working at the intersection of generative AI and biology. The ideal candidate will have a solid background in molecular biology, biochemistry, mammalian cell culture, and high-throughput screening techniques. You will collaborate with colleagues and work independently to develop and implement screening assays aimed at functionally testing and characterizing novel proteins generated through our proprietary models.This is a unique opportunity to contribute to an organization that advances artificial intelligence in addressing long-standing scientific challenges. A strong technical skill set, adaptability, organizational prowess, and exceptional communication abilities are essential, as is the capability to thrive both independently and as part of a dynamic, collaborative team.

What We Are Creating:At Medra, we are committed to harnessing the power of AI, robotics, and biology to expedite life science research, with the ultimate vision of eliminating diseases. We are in the process of developing our innovative Physical AI Scientist platform: A Physical AI capable of operating scientific instruments with remarkable human-level precision. A Scientific AI designed to autonomously analyze results, reason about subsequent steps, and complete the scientific loop.This is an ambitious endeavor, but we are confident that a team of dedicated individuals with a sense of ownership can achieve remarkable outcomes.Role Overview:As a scientist on our client-facing team, your primary goal will be to integrate closely with your scientific peers at our customer sites, acting as a true collaborator to ensure that the Medra platform is delivering scientific results and adding value to their organization. You will immerse yourself in the scientific needs of our customers, employing the scientific method (hypothesis formulation, experimental design, analysis) to validate the effectiveness of our Physical AI Scientist platform within their workflows. You will maintain continuous communication with our end users (scientists) to anticipate and address any challenges, while also relaying insights and feedback back to the company to inform product enhancements.Internally, you will collaborate closely with the engagement manager and deployed engineers to ensure a successful implementation. You will work alongside a distinguished team of robotics, software, and hardware engineers, providing scientific oversight throughout the scoping, building, and deployment phases. You will become a super-user of our platform, understanding its capabilities and constraints, and applying creativity and scientific intuition to tackle complex problems.We seek an individual who acts with urgency and thrives in high-pressure environments. This is a rare opportunity to leverage your expertise to effect transformative changes in drug discovery through artificial intelligence and robotics, offering significantly more exposure than traditional biotech or pharmaceutical roles.Key Responsibilities:Serve as the scientific subject matter expert - comprehend customer needs and provide biological insights to steer scoping, product development, and prioritization of features.Design and conduct wet-lab experiments to validate Medra’s autonomous Physical AI against scientific KPIs and metrics.Collaborate with cross-functional teams to ensure product alignment with scientific objectives.

Join Us in Revolutionizing Life Science ResearchAt Medra, our goal is to leverage artificial intelligence, robotics, and biological science to expedite research in life sciences, ultimately aiming to eliminate diseases. We are developing our Physical AI Scientist platform, which encompasses: Physical AI capable of manipulating scientific instruments with the dexterity akin to human hands. Scientific AI that autonomously analyzes results, evaluates subsequent steps, and completes the research loop.We are embarking on an ambitious journey, and we believe that a team of passionate individuals taking ownership can achieve remarkable milestones.Your Role in Our VisionAs a Scientist at Medra, you will spearhead the development and execution of antibody screening and characterization using our Physical AI platform. Your responsibilities will include supporting tissue culture operations, designing and conducting in vitro and cell-based assays for antibody candidates, and enhancing our lab capabilities through new assay formats and automated workflows.This position is ideal for someone who combines scientific acumen with practical skills—who has experience designing and implementing antibody characterization and functional assays in high-pressure environments and is excited by the prospect of transitioning hands-on expertise to an autonomous laboratory setting. You will collaborate closely with fellow scientists and roboticists to develop, validate, and operationalize assays on our platform.Key ResponsibilitiesDesign, execute, and analyze antibody screening and characterization campaigns from high-throughput primary hit triage to orthogonal confirmation.Develop and implement cell-based binding and functional assays using flow cytometry for characterizing antibodies, VHHs, and additional binder formats.Conduct biophysical characterization of antibody candidates, including SPR and BLI for assessing affinity and kinetics, and epitope binning—interpreting results to guide decision-making.Perform developability assays to evaluate manufacturability and risk factors—assessing thermal stability (DSF/DSC), aggregation and monomericity (HPLC-SEC), hydrophobicity (HPLC-HIC), polyspecificity/non-specific binding, and expression titer—assisting in candidate triage based on comprehensive characterization data.Maintain and engineer mammalian cell lines (e.g., Expi293, ExpiCHO, HEK293, CHO) and establish robust cell-based characterization and functional assays.

At Merge Labs, we are pioneering the intersection of biological and artificial intelligence, aiming to enhance human potential, agency, and overall experience. Our innovative research focuses on creating fundamentally new brain-computer interfaces that provide high-bandwidth interaction with the brain, seamlessly integrate with advanced AI, and prioritize safety and accessibility for all users.Team OverviewOur Bio team is at the forefront of designing, constructing, and characterizing the biotechnologies essential for next-generation brain-computer interfaces. We utilize molecular engineering, synthetic biology, and neuroscience, along with advanced physical techniques such as ultrasound, to forge less invasive, high-bandwidth connections with neuronal structures. The Bio team is responsible for developing our core molecular technologies, validating their efficacy both in vitro and in vivo, and demonstrating their advanced functionalities through animal model studies. We thrive on collaboration, working closely with engineers and data scientists, and fostering interdisciplinary creativity to tackle some of biotechnology's most pressing challenges.Role OverviewIn the position of Scientist in Cell Biology, you will be tasked with engineering neurons and various cell types to express innovative molecular biosensors and actuators, assessing their roles in enabling cellular interaction with ultrasound. Your research will encompass the study of biosensor expression, localization, degradation, and their effects on cellular function and health. You will devise protocols for cell culture, analysis, microscopy, and interactions with physical energies such as ultrasound. Your contributions will play a critical role in advancing groundbreaking molecular technologies geared towards neural interfacing and accelerating their clinical application.Key ResponsibilitiesOptimize and maintain mammalian cell preparations, including cell lines, primary and iPSC-derived neurons, brain organoids, or brain slices.Collaboratively innovate and construct novel protein and genetic constructs to facilitate biosensing and/or actuating capabilities.Develop and execute cell engineering workflows, encompassing construct delivery, selection, and differentiation processes.Characterize construct functionality and assess cellular impact using techniques such as activity recording, microscopy, stimulation, flow cytometry, immunohistochemistry, and next-gen sequencing.Engage in collaborations with cross-disciplinary teams, integrating expertise from protein engineering, biochemistry, cell biology, neuroscience, and genetics.

About NudgeNudge is on a transformative mission to harness advanced technology that interfaces with the brain to enhance human life. Our pioneering focus is on creating a cutting-edge, non-invasive ultrasound device capable of stimulating and imaging the brain with unparalleled resolution. This initiative integrates innovative hardware, software, and research methodologies to develop life-changing products that can eventually benefit millions, if not billions, of individuals.About the RoleAs a Research Scientist specializing in Cell Biology at Nudge, you will:Innovate techniques to characterize the mechanisms by which ultrasound affects neural tissue.Design and conduct in vitro experiments to assess the influence of ultrasound on cellular characteristics, activity, and plasticity.Optimize ultrasound parameters to enhance cellular activity and promote plasticity.Translate findings from in vitro studies to guide human neuromodulation research.About YouWe are looking for research scientists at various stages of their careers. Regardless of your level, you should possess:A PhD or postdoctoral experience in neuroscience, molecular/cellular biology, biomedical engineering, or a related field.Expertise in neural cell culture or slice methodologies, with a preference for human neural iPSC techniques.Experience in calcium imaging, functional imaging analysis, two-photon microscopy, or other advanced imaging techniques.Proficiency in electrophysiology, voltammetry, or other neural recording methodologies.A proven track record of significant technical contributions.A commitment to high integrity and ethical research practices.

insitro blends AI, large-scale biology, and drug discovery into a unified process. Predictive models guide laboratory experiments, while experimental results feed back to improve those models. This feedback loop aims to create a more efficient path from data to discovery. Role overview The Scientist I/II in Integrated Technology and Exploration designs and executes cell-based experiments, using both manual and automated workflows. The work focuses on generating key datasets that support and improve insitro’s predictive models. AI-generated predictions serve as hypotheses, which are tested at the bench. When results diverge from predictions, the scientist investigates whether the issue lies in the model, the experimental design, or the broader framework. Each experiment helps the system learn and become more accurate over time. What success looks like Consistent, high-quality execution of experiments that inform and refine predictive models Evidence-based contributions that improve the accuracy, calibration, and usefulness of the overall system Requirements Strong background in cell biology Comfort working at the intersection of experimental biology and computational modeling Curiosity and motivation to develop systems that improve through real-world data Work location and reporting This position is based onsite at insitro’s South San Francisco headquarters. Presence is required five days a week to maintain rapid feedback between experiments, automation, and AI analysis. The Scientist I/II reports to the Director of Integrated Technology Exploration.

About Rezo TherapeuticsRezo Therapeutics is an innovative biopharmaceutical company dedicated to revolutionizing drug development. Our vision is to significantly enhance the success rate of drug discovery through a comprehensive, disease-agnostic network biology platform that transforms our understanding of human diseases and their treatments. We employ a unique, integrated strategy that merges genetics, proteomics, structural biology, and artificial intelligence to yield profound biological insights and to create novel therapeutic strategies. Situated in the vibrant Mission Bay neighborhood of San Francisco, Rezo enjoys proximity to UCSF, diverse urban amenities, and abundant outdoor recreational activities. We understand that our mission's success relies equally on our talented team and our scientific endeavors, which is why we are committed to fostering a collaborative, respectful, and diverse workplace where team contributions are as valued as individual accomplishments. If you are driven by team science and eager to dismantle barriers in drug development, we invite you to consider joining us!The OpportunityWe are seeking a Senior Scientist in Discovery Biology to join our esteemed Biology Team. In this pivotal role, you will collaborate with a multidisciplinary team of experts in genetics, proteomics, structural biology, and artificial intelligence to address complex biological challenges and develop groundbreaking therapies. This is an exceptional opportunity to apply your expertise in cancer biology to design and implement advanced cellular assays for target validation and compound screening. By joining Rezo at this exciting stage, you will have the opportunity to make a significant impact in a dynamic, collaborative setting.

Merge Labs is an innovative research facility dedicated to uniting biological systems with artificial intelligence to enhance human capabilities, autonomy, and experiences. We are committed to this aim by creating groundbreaking methods for brain-computer interfaces that allow high-bandwidth interactions with the brain, integrate advanced AI systems, and ensure safety and accessibility for all users.About the TeamOur team at Merge Labs focuses on advanced techniques for brain interfacing at high bandwidth by developing pioneering technologies that merge biomolecular science, physics, neuroscience, and computational methods. The Bio team is responsible for creating our essential molecular technologies, validating their efficacy both in vitro and in vivo, and showcasing their capabilities in animal models. We build custom experimental frameworks, collaborate closely with engineers and data scientists, and engage in creative problem-solving across various disciplines.About the RoleAs a Scientist specializing in In Vivo Molecular Neurotechnology at Merge Labs, you will play a crucial role in advancing molecular biosensors and actuators for brain-computer interface technologies. Your responsibilities will include establishing experimental frameworks to optimize the delivery and functional expression of biomolecules in rodent models, assessing their tolerability and biological impacts, benchmarking their performance in neuroscience paradigms, and generating insights to inform the design of next-generation technologies. You will work collaboratively with molecular engineers, data scientists, and physical engineers to address challenges and innovate solutions. Your contributions will drive breakthroughs in neural interfacing technology, facilitating its clinical applications.Key Responsibilities:Lead and expand in vivo validation pipelines in rodent models for molecular biosensors and actuators, which includes gene delivery methods, surgical workflows, sensory and behavioral paradigms, and ex vivo characterization.Enhance delivery vehicles, administration techniques, and parameters to ensure robust, cell-type specific expression, while quantifying outcomes at both functional and molecular levels.Design and conduct in vivo experiments to evaluate the functional performance of biosensors and actuators in relevant neuroscience contexts.Collaborate with hardware engineers and platform teams to develop and construct custom setups incorporating novel imaging and modulation instruments.

Our MissionAt Altos Labs, we are dedicated to revitalizing cell health and resilience through innovative cell rejuvenation techniques to reverse disease, injury, and the disabilities that arise throughout life.Discover more about our vision at altoslabs.com.Our ValuesOur core value is simple yet powerful: Everyone Owns Achieving Our Inspiring Mission.Diversity at AltosWe understand that diverse perspectives are crucial for scientific breakthroughs and exploration. At Altos, exceptional scientists and industry leaders collaborate from around the globe to drive our shared mission forward. We prioritize a culture of belonging, ensuring that every employee feels valued for their unique contributions. We are all responsible for maintaining a diverse and inclusive workplace.Your Contributions to AltosJoin Altos Labs in creating a premier AI ecosystem aimed at addressing the most intricate challenges in human biology. You will be instrumental in designing and developing high-performance, scalable solutions that integrate high-dimensional biomedical imaging with molecular and linguistic data.Your role will involve implementing large-scale multimodal data fusion, advancing beyond basic image analysis to develop predictive models that span various biological domains. You will engage directly with data and coding, partnering with our engineering team to ensure these models are scalable, efficiently trainable in distributed cloud environments, and accessible to our global research network.Key ResponsibilitiesModel Development: Create, implement, and train large-scale foundational models (e.g., Vision Transformers, Multimodal LLMs) capable of embedding spatial data and integrating diverse modalities.Innovative Data Fusion: Apply cutting-edge cross-domain mapping and fusion techniques to align heterogeneous biological datasets.Scaling & Training: Develop and oversee high-performance ML pipelines designed to handle petabyte-scale image collections and multi-omics data streams in a cloud infrastructure.Technical Collaboration: Work closely with experimental scientists and software engineers to convert biological complexity into high-performance code and reliable distributed systems.Who You AreWe seek a technical expert who excels at unraveling "unsolvable" challenges through programming and meticulous experimentation. We welcome candidates at the Scientist I, Scientist II, or Senior Scientist levels.

Join Multiply Labs as a Scientist IIAt Multiply Labs, an innovative startup located in the heart of San Francisco, California, we are on a mission to revolutionize the accessibility of advanced life-saving therapies. Backed by renowned investors such as Casdin Capital, Lux Capital, and Y Combinator, our goal is to develop the most sophisticated robotic systems in the world to automate and enhance the manufacturing of cell therapies.Our state-of-the-art robotic solutions empower biopharma companies to produce cell therapies at scale, minimizing regulatory hurdles and costs that traditionally exceed $1 million per patient. By leveraging automation, we aim to make these groundbreaking treatments more affordable and accessible to those in need.To witness our technology in action, visit us at www.multiplylabs.com and connect with us on LinkedIn.Position OverviewWe are looking for a passionate Scientist II to play a vital role in advancing and validating our automated processes. This position will primarily entail hands-on laboratory work, where you will enhance the efficiency, accuracy, and reliability of our robotic systems, gaining an in-depth understanding of our innovative technology. Additionally, you will serve as a key representative of Multiply Labs during client system deployments, collaborating directly with customers to ensure the seamless integration and optimal performance of our robotic solutions, thus contributing significantly to their success.

Join our innovative team at Mindlance as an Associate Scientist. In this role, you will contribute to groundbreaking research and development projects that drive our mission forward. Your work will involve collaborating with cross-functional teams to analyze data, conduct experiments, and support various scientific initiatives. This position is ideal for individuals looking to advance their careers in a dynamic and supportive environment.

We are seeking a highly motivated and talented Senior Associate Scientist to join our dynamic team in San Francisco. In this role, you will collaborate with cross-functional teams to advance our scientific initiatives and contribute to groundbreaking research. You will have the opportunity to work with cutting-edge technologies and methodologies, driving innovation within our organization.

We are seeking an ambitious and organized Chief of Staff to join our dynamic team in San Francisco. This role is pivotal in helping us scale our operations and navigate through the exciting challenges of growth.As Chief of Staff, you will collaborate closely with the CEO to define and streamline our operational cadence. You will take charge of executing essential tasks across various functions, including recruitment, finance, and the implementation of new initiatives. Being part of a lean team means your decisions will directly impact our trajectory, and you will have the autonomy to shape our processes and outcomes.Key ResponsibilitiesOversee internal operations, including financial management and human resourcesManage day-to-day administrative tasks such as payroll, expense tracking, and vendor relationsLead recruitment efforts, conduct interviews, and onboard new team membersDrive new initiatives and special projects focused on growth, sales, marketing, and partnershipsSupport the go-to-market strategy for the enterpriseDevelop and automate processes that enhance efficiency as we scaleThis is a high-impact role for a motivated individual eager to become a top-tier operator. You will gain hands-on experience across various domains such as recruitment, marketing, operations, and customer development. As our company expands, so will the scope of your responsibilities and opportunities.

Join Our Team as a Software EngineerAt intrinsic-safety, we are at the forefront of developing AI agents that tackle complex decision-making in risk investigations, fraud detection, and identity verification. Our mission revolves around empowering machines to make the most challenging judgment calls efficiently and accurately.As a dynamic and compact team based in San Francisco, we are addressing challenges that impact billions of transactions and entities. Our clientele includes renowned Fortune 500 companies, global marketplaces, and regulated financial institutions. If you are driven by ownership, quick execution, and collaboration with founders, you will thrive here.

Role OverviewAt Variance, we are at the forefront of teaching machines to execute high-stakes judgment calls on a large scale. This involves developing AI agents that navigate the complex domains of risk investigations, fraud detection, and identity verifications.Our San Francisco-based team is small yet exceptionally talented, comprising former founders and specialists from leading AI laboratories. We cater to an impressive clientele, including Fortune 500 companies, global marketplaces, and regulated financial institutions. If you are passionate about taking ownership, working swiftly, and collaborating closely with founders, you will thrive in our environment.We are seeking a Security Engineer to help establish a robust security foundation. You will collaborate across product, infrastructure, and internal systems to ensure that Variance is secure by design, enabling us to meet the rigorous standards needed to deploy AI in critical workflows for the world’s largest corporations.

Join our dynamic team at Intrinsic Safety as an Enterprise Account Executive. In this pivotal role, you will be responsible for driving sales and fostering relationships with key enterprise clients. Your expertise will contribute to the growth and success of our innovative safety solutions.We are looking for a passionate professional who thrives in a fast-paced environment, excels in building strong client connections, and is driven to achieve targets. You will work closely with cross-functional teams to deliver outstanding service and value to our clients.

Role OverviewAt Intrinsic Safety, we are pioneering the development of AI systems capable of making critical decisions in high-stakes environments such as risk investigations, fraud detection, and identity verification. Our dedicated team in San Francisco is at the forefront of tackling complex challenges where traditional AI solutions often fall short.We are in search of a Research Engineer to play a pivotal role in shaping our model evaluation strategies. You will be responsible for creating benchmarks, datasets, and evaluation frameworks that accurately assess our systems’ performance in real-world scenarios. This position bridges research, product development, and engineering, focusing on rigorous evaluations that reflect actual customer workflows and identify key failure points to propel the next generation of AI advancements.