Associate Scientist - High-Throughput Protein Therapeutics

Xaira Therapeutics is a biotech startup based in the San Francisco Bay Area, with additional offices in Seattle and London. The company applies artificial intelligence to drug discovery and development, building generative AI models to design protein and antibody therapeutics for challenging molecular targets. Xaira also develops foundational models in biolo…

About Xaira TherapeuticsXaira Therapeutics is a pioneering biotech startup that harnesses the power of artificial intelligence to revolutionize drug discovery and development. Our mission is to develop cutting-edge generative AI models that design innovative protein and antibody therapeutics, paving the way for the creation of medicines targeting previously challenging molecular targets. In addition, we are developing foundational models for biology and disease that enhance target elucidation and patient stratification. These technologies collectively aim to facilitate the ongoing discovery of novel therapies and improve the likelihood of success in drug development. Xaira proudly operates from the vibrant San Francisco Bay Area, Seattle, and London.About the RoleAs a Principal Associate Scientist within our Protein Engineering group, you will play a vital role in our interdisciplinary team composed of highly creative and skilled professionals with exceptional expertise in protein characterization and engineering. This group is instrumental in driving our AI drug discovery initiatives and optimizing lead molecules. You will collaborate closely with protein designers, biologists, and other members of the drug discovery team.We are seeking an exceptional library builder who possesses the ability to design, generate, and scale complex DNA assemblies for our protein engineering and display teams. This role demands extensive experience in combinatorial, designed, and naive library building, along with the necessary microbiological and protein-level expertise to express and qualify these assemblies once constructed. This hands-on position is ideal for someone who can seamlessly integrate NGS, protein biochemistry, and DNA assembly needs while building complex libraries efficiently.About YouYou are a passionate protein biochemist who takes pride in your laboratory skills. Your enthusiasm lies in display technology, drug discovery, and the development of innovative treatments for patients. You are detail-oriented, organized, and thrive on collaboration. You flourish in a fast-paced environment where pushing the boundaries of what is possible is the norm.What You'll Do and LearnDesign and implement various innovative selection techniques using synthetic libraries, including phage, yeast, and mammalian display.Utilize FACS sorting, plate-based screening, and NGS to identify binders.Establish and employ automation to further rank leads based on affinity and function.Collaborate with cross-functional teams to troubleshoot protein reagents.Train and mentor junior team members.

Join Tahoe Therapeutics as a Senior Machine Learning Scientist!At Tahoe Therapeutics, we are at the forefront of revolutionizing drug discovery by leveraging real patient biology. Our innovative Mosaic platform enables scalable in vivo data generation at single-cell resolution, allowing for intricate mapping of drug effects on patient-derived cells across diverse biological contexts. As we develop the world’s most comprehensive in vivo single-cell perturbation atlas, we harness cutting-edge machine learning techniques combined with the richest biological datasets to accelerate the discovery of effective drugs for those who need them most.Your Role:As a Senior Machine Learning Scientist, you will be instrumental in designing the next generation of foundation models that elucidate gene regulatory networks, utilizing our extensive single-cell datasets such as Tahoe-100M. This position is ideal for individuals with a profound understanding of machine learning and statistics, eager to apply groundbreaking ML advancements to impactful challenges in drug discovery. We seek innovative thinkers who can contribute to the creation of models that will significantly influence the field of drug development.

Join Xaira Therapeutics as a Senior Research Associate Scientist specializing in Display Technologies. In this pivotal role, you will be at the forefront of groundbreaking research and development initiatives that are shaping the future of therapeutic solutions. Your expertise will directly contribute to the innovation of our display technology, enhancing our product offerings and impacting the lives of patients worldwide.

Join our dynamic team at Mindlance as an Associate Scientist. In this pivotal role, you will contribute to groundbreaking research initiatives and assist in the development of innovative solutions within the scientific community. Your expertise and analytical skills will help drive forward our mission to advance scientific knowledge and technology.

About Xaira TherapeuticsXaira Therapeutics is a pioneering biotech startup harnessing the power of artificial intelligence to revolutionize drug discovery and development. Our mission is to lead the way in developing generative AI models for designing innovative protein and antibody therapeutics, paving the path for medicines targeting traditionally challenging molecular targets. We are also focused on creating foundational models for biology and disease to enhance target elucidation and patient stratification. Together, these cutting-edge technologies are designed to continually facilitate the discovery of novel therapies and enhance success rates in drug development. Our headquarters are located in the vibrant San Francisco Bay Area, Seattle, and London.About the RoleXaira Therapeutics is on the lookout for a lab-based Senior Scientist specializing in Inflammation and Immunology to join our Biology & Pharmacology department. This position is perfect for an individual who excels in a hands-on research setting, possesses experience working with primary human or mouse immune cells, and is eager to influence the strategy of therapeutic programs.As a Senior Scientist, you will explore disease biology and drug mechanisms, generate impactful data, and collaborate across teams to advance our therapeutic initiatives.What You’ll DoLead preclinical programs by designing and conducting in vitro and in vivo studies to investigate disease biology, validate targets, and develop lead candidates.Identify critical knowledge gaps, pose essential mechanistic questions to steer program direction, and assess new targets and therapeutic strategies.Dissociate human tissue biopsies into single-cell suspensions or establish human tissue slice cultures for subsequent functional or phenotyping assays.Conduct immune profiling and functional characterization using advanced high-parameter flow cytometry (15+ colors or spectral platforms), functional assays (T cell activation, differentiation, proliferation, suppression), and molecular/cytokine profiling (MSD, Luminex, qPCR, RNA sequencing).Convert experimental data into actionable insights and effectively communicate findings and recommendations to cross-functional teams.

About Xaira TherapeuticsXaira Therapeutics is a pioneering biotech startup dedicated to revolutionizing drug discovery and development through the power of artificial intelligence (AI). Our mission is to lead the advancement of generative AI models designed specifically for creating innovative protein and antibody therapeutics. This allows us to tackle previously challenging molecular targets and develop effective medicines. We are also at the forefront of developing foundational models for biology and disease, facilitating improved target identification and patient stratification. Through our cutting-edge technologies, we aim to consistently discover novel therapies and enhance the success rates of drug development. Xaira has its headquarters in the vibrant San Francisco Bay Area, Seattle, and London.Position OverviewWe are on the lookout for dynamic and passionate candidates to join our innovative team as an AI Scientist! In this role, you will leverage your experience in developing and implementing advanced deep learning methodologies, showcasing a proven record of AI innovation through publications in the fields of Artificial Intelligence or Machine Learning, or through significant interdisciplinary projects. As a vital member of our core AI team, composed of exceptionally talented and creative individuals, you will spearhead exciting projects aimed at advancing state-of-the-art AI models in biology that influence drug discovery and clinical development. This role also provides the opportunity to collaborate with interdisciplinary experts in world-class biology, drug discovery, and clinical domains. Xaira values diversity and encourages candidates from all backgrounds and experiences to apply, as we believe that teams thrive when varied perspectives are included.The position is available in the following locations: San Francisco Bay Area, Seattle, and London.

About Xaira TherapeuticsXaira Therapeutics is a cutting-edge biotechnology startup that harnesses the power of artificial intelligence to revolutionize drug discovery and development. Our mission is to pioneer generative AI models that design innovative protein and antibody therapeutics, targeting previously challenging molecular entities. We are also creating foundational models to enhance biological and disease understanding, facilitating improved target identification and patient stratification. Our technologies aim to consistently identify breakthrough therapies and elevate success rates in drug development. Xaira is proudly headquartered in the San Francisco Bay Area, with additional locations in Seattle and London.About the RoleWe are seeking a passionate and detail-oriented protein biochemist who excels in hands-on laboratory execution. Your enthusiasm for display technology and drug discovery will drive you as you work towards developing transformative treatments for patients. You thrive in collaborative and fast-paced settings, continuously seeking to push the frontiers of scientific innovation.

Who We Are: Calico Life Sciences LLC is a pioneering research and development organization founded by Alphabet, dedicated to advancing the understanding of human aging through cutting-edge technologies and model systems. Our mission is to leverage this knowledge to develop interventions that promote longer, healthier lives. With a vibrant pipeline of drug development, innovative laboratory technologies, and a commitment to curiosity-driven discovery, Calico is a dynamic environment for driving impactful medical breakthroughs. Position Overview: We are on the lookout for a highly skilled and driven Principal Associate Scientist to lead our Biomarker Group in discovering and validating pharmacodynamic, prognostic, and predictive biomarker assays. This role supports a diverse array of clinical programs, including those focused on Neuroscience, Oncology, and aging-related diseases. The ideal candidate will possess over 15 years of experience in translational biology, molecular and cellular biology, and hands-on assay development, bridging the gap between early discovery and clinical development to ensure that our therapeutic candidates are underpinned by solid biomarker strategies. Key Responsibilities: Discovery & Validation: Lead the discovery and validation of pharmacodynamic biomarkers to support the clinical development of drugs with innovative mechanisms of action using preclinical models (both in vivo and in vitro) and human specimens. Assay Development: Spearhead the development, optimization, and qualification of biomarker assays across various platforms. Data Analysis & Interpretation: Conduct thorough analyses to establish pharmacokinetic/pharmacodynamic relationships and benchmark program compounds, utilizing statistical and specialized tools to interpret results from ex-vivo and in-vitro studies, delivering actionable insights for clinical dose selection, and synthesizing complex biological data into concise reports for senior management. Clinical Translation: Manage the technical transfer of validated assays to CROs or internal bioanalysis teams for Phase I/II studies. Strategic Intelligence: Gather and analyze competitive intelligence to guide discovery strategy and provide scenario assessments for high-priority clinical assets. Mentorship: Mentor and manage junior scientists, fostering a culture of technical excellence and scientific inquiry.

About Us: Calico Life Sciences LLC, a pioneering research and development organization established by Alphabet, is dedicated to leveraging cutting-edge technologies and modeling systems to deepen our understanding of the biology underlying human aging. Our goal is to translate this knowledge into interventions that empower individuals to live longer, healthier lives. With a foundation in curiosity-driven scientific discovery and a robust drug-development pipeline in collaboration with academic and industry partners, Calico offers a dynamic environment for fostering innovative medical breakthroughs. Position Overview: We are on the lookout for a visionary Principal Scientist to connect computational design with experimental validation in our antibody discovery process. In this pivotal role, you will act as the key scientific liaison between our wet-lab antibody team and machine learning group, propelling the advancement of our "Design-Build-Test-Learn" framework. As both a project leader and technical authority, you will convert intricate in silico designs into practical experimental workflows. You will oversee the rigorous validation of computational predictions and ensure that the resulting biological data is organized to enhance and refine our internal models. We are seeking a seasoned expert in therapeutic antibody development who is eager to transcend traditional random screening methodologies and promote a rational, data-driven paradigm in biologic drug discovery.

The OpportunityAt insitro, machine learning is at the forefront of our innovative approach to drug development. Our unique TherML Platform harnesses AI to expedite therapeutic discovery across various modalities, from initial hit identification to lead optimization. This pioneering strategy allows us to swiftly design therapeutics targeting novel, internally discovered targets, utilizing extensive datasets recognized as some of the largest and most comprehensive in the industry.We are currently seeking a Machine Learning Scientist who will actively engage with our TherML platform to spearhead the design of multiple oligonucleotide therapeutic programs while directly influencing the enhancement of our platform and machine learning models. This position presents an exciting opportunity to translate state-of-the-art machine learning into tangible advancements in drug discovery. The role reports to the Senior Manager of Molecular Machine Learning and offers a flexible hybrid working model (2 days in-office per week) or remote work (one week on-site per quarter).

Vilya is at the forefront of computational biotechnology, developing an innovative class of medicines designed to precisely target disease biology. We are committed to integrating computational strategies as a core aspect of drug discovery and development. Our advanced platform is founded on pioneering research and explores uncharted chemical spaces to create new molecular structures that do not exist in nature.We are leveraging our platform's capabilities to tackle previously unattainable targets across a wide range of medical indications. Vilya’s ultimate ambition is to address some of the most significant unmet medical needs of our time.Our Vision: To revolutionize technology and biology for the enhancement of human health.Our Mission: To establish an independent, leading biotech company grounded in intelligent drug design, aiming to cure the incurable.We are looking for a driven and enthusiastic Summer Intern to join our Structural Biology and Biology teams in South San Francisco for a 12-week internship in the summer of 2026. Reporting to the Director of Structural Biology, this in-office position will be vital in advancing our platform technology and facilitating the transition of orally available macrocycles into clinical settings.

About Us: Calico Life Sciences LLC, a research and development organization backed by Alphabet, is dedicated to advancing our understanding of the biological mechanisms governing human aging. Our mission is to leverage cutting-edge technologies and sophisticated model systems to create interventions that promote longer, healthier lives. At Calico, we foster an environment of curiosity-driven scientific exploration, collaborating with academic and industry partners to accelerate medical breakthroughs. Position Overview: We are on the lookout for a Senior Machine Learning Scientist/Engineer to innovate and implement machine learning algorithms aimed at modeling and designing proteins. In this role, you will collaborate closely with a team of experienced experimental biologists to design experiments that test and refine our machine learning predictions iteratively. The ideal candidate will possess a deep understanding of contemporary machine learning methodologies, including language and sequence modeling, representation learning, generative models, and self-supervised learning techniques. You should have a proven track record in implementing, enhancing, and debugging advanced machine learning models, alongside expertise in building robust data infrastructures and tools. We seek a proactive, self-driven individual eager to explore the latest ML literature and apply innovative solutions to protein design challenges at Calico. Strong communication skills are essential, as you will need to effectively share your findings through publications and presentations and collaborate across teams to navigate complex projects.

About Xaira TherapeuticsXaira Therapeutics is a pioneering biotech startup dedicated to harnessing the power of artificial intelligence to revolutionize drug discovery and development. Our company is at the forefront of creating generative AI models that design innovative protein and antibody therapeutics, aiming to produce medicines that target historically challenging molecular entities. We are also advancing foundational models for biology and disease, which facilitate better target identification and patient stratification. Our technologies collectively strive to continually unveil novel therapies and enhance success rates in drug development. Headquartered in the vibrant San Francisco Bay Area, with additional offices in Seattle and London, Xaira is shaping the future of medicine.About the RoleWe are on the lookout for a passionate Scientist with robust hands-on molecular biology expertise and a creative, analytical, and innovative approach. This position emphasizes aiding in the design, construction, and refinement of cutting-edge screening platforms and experimental workflows that drive biological discoveries at scale.The ideal candidate is a proactive individual who thrives in uncertain problem spaces, meticulously considers experimental design, and takes initiative in transforming initial concepts into dependable, reproducible systems. You will engage collaboratively with various teams, including automation, engineering, and computation, to invent new methodologies for generating high-quality biological data.

Join Artech Information Systems LLC as an Associate Scientist II in Product Assurance, where you will play a pivotal role in ensuring the quality and reliability of our innovative products. You will collaborate with a dynamic team to perform testing and validation, contributing to the development of cutting-edge technologies.

Insitro, Inc. seeks an Associate Scientist III to join its team in South San Francisco. This position focuses on developing and refining methods to differentiate induced pluripotent stem cells (iPSCs) into mature cell types, particularly microglia and astrocytes, using samples from a range of patient donor lines. The work plays a key role in disease modeling and deepens the company’s insight into human biology. What you will do Adapt and optimize transcription factor-driven and directed differentiation protocols for iPSCs, with special attention to large-scale production. Develop and standardize quality control assays and cryopreservation strategies for progenitor cell banks. Execute co-culture and tri-culture in vitro models to study cellular interactions. Engineer iPSC lines by introducing transcription factor-expression cassettes using piggy-back transposon, viral transduction, and lipofectamine methods. Characterize in vitro models with flow cytometry, immunocytochemistry, and transcriptomics. Validate model functionality using live-cell assays. Scale and perform quality control assays for various mammalian cell types, using automated high-content microscopy. Work with cross-functional teams to bring automation solutions into cell biology workflows. Deliver high-quality iPSC-derived cellular data to support predictive machine learning model development. Share data and project updates in team and company-wide meetings. Location This role is based in South San Francisco, CA.

Join Alector as the Senior Director of CMC Technical Operations, where you will lead innovative efforts in the development of siRNA therapeutics. This pivotal role involves overseeing the entire lifecycle of CMC activities, ensuring regulatory compliance, and driving the strategic direction of our product pipeline. Your expertise will be instrumental in collaborating with cross-functional teams to advance our mission of harnessing the power of RNA therapeutics.

About Us: Calico Life Sciences LLC, a cutting-edge research and development firm founded by Alphabet, is dedicated to unraveling the complexities of human aging through advanced technologies and innovative model systems. Our mission is to leverage this understanding to create interventions that promote longer, healthier lives. With state-of-the-art technology labs, a culture of curiosity-driven discovery, and a robust pipeline of drug development in collaboration with both academic and industry partners, Calico is an inspiring environment for catalyzing medical breakthroughs. Job Overview: We are on the lookout for a dynamic and passionate Scientist/Senior Scientist in Aging Biology to become a pivotal member of our Translational Medicine team. In this vital role, you will investigate the mechanisms of action (MOA) of therapeutic targets within our aging biology pipeline. The successful candidate will define the molecular and cellular pathways integral to our research programs, translating novel in vivo findings into a profound mechanistic understanding that will guide clinical development. The ideal candidate will possess substantial expertise in cell biology, MOA studies, and complex signaling pathways. Key Responsibilities: Design and implement experimental strategies to elucidate the molecular and cellular mechanisms of action for aging-related targets and biomarkers, providing insights that steer program direction. Execute in vitro and ex vivo studies to explore target biology in significant aging-related processes, such as stem cell function, tissue repair, and signaling or transcriptional regulation. Analyze acute and chronic pathway modulation in tissue injury and aging models to comprehend the evolution of stress responses and repair mechanisms in aging. Investigate the molecular drivers of in vivo phenotypes in preclinical aging models to identify biomarkers and translatable mechanisms for clinical development. Collaborate with in vivo pharmacology and biomarker teams to select optimal preclinical models that effectively probe target biology. Engage with cross-functional teams (e.g., Biomarkers, Genomics, Protein Sciences) to integrate multi-omic datasets and construct a comprehensive mechanistic framework. Analyze, interpret, and present complex data along with strategic recommendations to internal project teams and senior leadership. Maintain rigorous experimental documentation and contribute to internal reports, publications, and regulatory submissions.

At Structure Therapeutics, we are dedicated to developing transformative medicines for patients utilizing cutting-edge structure-based and computational drug discovery technologies. Our innovative platform merges the latest breakthroughs in molecular interaction visualization, computational chemistry, and data integration to create superior oral small molecule medicines that address the limitations of current biologic and peptide drugs. We are actively progressing a clinical-stage pipeline of unique treatments targeting chronic diseases with significant unmet needs, particularly in cardiovascular, metabolic, and pulmonary health.Our leadership team consists of renowned international drug innovators, supported by top-tier global life sciences investors. Having completed our IPO in February 2023, we operate offices in California and Shanghai, leveraging the strengths of both regions to be at the forefront of life science innovation.

Join Tahoe Therapeutics as a Senior Machine Learning EngineerAt Tahoe Therapeutics, we are transforming drug discovery with our innovative approach that prioritizes the biology of real patients. Our groundbreaking Mosaic platform allows for scalable in vivo data generation at single-cell resolution, enabling us to understand how drugs impact patient-derived cells across diverse biological contexts. We are committed to constructing the world’s largest in vivo single-cell perturbation atlas and utilizing it to develop multimodal foundation models that elucidate the context-dependent dynamics of gene function, disease progression, and drug responses.Our mission is clear: to expedite the discovery of superior drugs and ensure they reach the patients who need them the most by leveraging advanced machine learning techniques alongside the most biologically pertinent datasets in drug discovery.Your ContributionsAs a Senior Machine Learning Engineer, you will lead the design of the next generation of foundation models for gene regulatory networks, drawing on Tahoe’s extensive single-cell datasets such as Tahoe-100M and beyond. This role is tailored for individuals with a robust background in machine learning and statistics, coupled with a passion for applying innovative ML developments to impactful challenges in drug discovery. We seek unconventional thinkers ready to advance the frontiers of possibility in our field.