Principal Machine Learning Data Scientist Generative Ai jobs in Waltham – Browse 72 openings on RoboApply Jobs

Principal Machine Learning Data Scientist Generative Ai jobs in Waltham

Open roles matching “Principal Machine Learning Data Scientist Generative Ai” with location signals for Waltham. 72 active listings on RoboApply Jobs.

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companyXometry logo
Full-time|$164K/yr - $213K/yr|On-site|Waltham, MA

Xometry (NASDAQ: XMTR) is at the forefront of innovation, bridging the gap between visionary thinkers and the manufacturers who actualize their ideas. Our cutting-edge digital marketplace equips manufacturers with vital resources to scale their businesses while enabling Fortune 1000 companies to seamlessly access global manufacturing capabilities.We are on the lookout for a Principal Data & ML Scientist to join our Generative AI team. The perfect candidate will be enthusiastic about driving advancements in machine learning and generative AI, especially in fine-tuning generative and language models, multimodal document comprehension, and structured data extraction. You will utilize your deep knowledge of generative models and data science to create and refine innovative AI-driven solutions that elevate Xometry's service offerings.

Feb 2, 2026
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companyXometry logo
Full-time|$140K/yr - $230K/yr|On-site|Waltham, MA

At Xometry (NASDAQ: XMTR), we empower the industries of today and tomorrow by bridging innovative thinkers with manufacturers capable of making their visions a reality. Our digital marketplace equips manufacturers with essential resources for growth while allowing buyers from Fortune 1000 companies to seamlessly access global manufacturing capabilities.We are searching for a Staff Machine Learning Engineer to spearhead our Generative AI initiatives. This is a unique opportunity to redefine the future of manufacturing by leveraging advanced AI research to solve practical challenges—from multimodal document comprehension and structured data extraction from technical drawings to developing innovative reasoning methods across text, images, and 3D data. If you are enthusiastic about crafting cutting-edge AI systems and are eager to witness your contributions making a direct impact on business and customer satisfaction, we would love to hear from you.

Feb 2, 2026
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companyXometry logo
Full-time|$150K/yr - $196K/yr|On-site|Waltham, MA

Xometry (NASDAQ: XMTR) is at the forefront of innovation, transforming industries by linking visionary thinkers with manufacturers capable of turning ideas into reality. Our digital marketplace equips manufacturers with essential resources for business growth while simplifying access to global manufacturing capabilities for Fortune 1000 companies.We are on the lookout for a Senior Principal, Machine Learning & Artificial Intelligence to join our dynamic team. In this pivotal role, you will lead the charge on significant, cross-functional ML/AI initiatives, driving substantial and enduring business impact. Your responsibilities will include steering a comprehensive 18- to 24-month technical roadmap that harmonizes cutting-edge innovation with tangible business value. Collaborating closely with engineering, product, design, manufacturing operations, and business leadership, you will influence partner roadmaps and resource allocation. As a respected subject-matter expert, you will proactively eliminate obstacles for teams and tackle challenges beyond your immediate domain. Your focus will be on identifying and spearheading initiatives that foster revenue growth, reduce costs, enhance efficiency, and establish competitive differentiation—particularly in areas such as 2D/3D part understanding, generative AI, and advanced machine-learning platforms.

Feb 2, 2026
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companyXometry logo
Internship|$27/hr - $27/hr|On-site|Waltham, MA

Xometry (NASDAQ: XMTR) is at the forefront of innovation, bridging the gap between visionary thinkers and the manufacturers capable of turning those ideas into reality. Our digital marketplace equips manufacturers with essential resources to expand their operations while enabling Fortune 1000 companies to seamlessly access global manufacturing capabilities.Are you an ambitious college student looking to make a significant impact within a leading technology firm? Join Xometry's Summer Internship Program to gain invaluable hands-on experience and cultivate key skills in the manufacturing sector.As a Machine Learning Intern at Xometry, you'll tackle real-world challenges that influence our AI solutions, collaborate with seasoned machine learning engineers, and gain insights on creating and deploying models that address intricate problems in a vibrant and fast-paced setting.

Feb 2, 2026
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companyXometry logo
Full-time|$140K/yr - $182K/yr|On-site|Waltham, MA

Xometry (NASDAQ: XMTR) is at the forefront of innovation, connecting visionary thinkers with manufacturers equipped to turn their concepts into reality. Our digital marketplace empowers manufacturers with essential resources for growth, while facilitating access to global manufacturing capabilities for buyers from Fortune 1000 companies.We are currently searching for a Senior Data Scientist to join our dynamic sourcing team. The ideal candidate will possess a strong enthusiasm for applying machine learning techniques to build, refine, and assess predictive models that forecast various business outcomes. This role requires a deep understanding of probability and statistics to draw meaningful and defensible insights from data.

Feb 2, 2026
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company
Full-time|$129K/yr - $209K/yr|On-site|Waltham, Massachusetts, United States

Join Our Team!Become a pivotal member of the Evolv Machine Learning & Sensors team as a Senior Data Scientist. In this role, you will delve into sensor data, explore feature spaces, and ensure data quality that fuels our cutting-edge AI/ML systems. This hands-on position focuses on representation analysis, extracting exploratory data insights, and implementing data-centric enhancements that significantly elevate model accuracy, robustness, and generalization. You will navigate through classical ML and deep learning pipelines to uncover blind spots, diagnose data challenges, and shape effective data curation and collection strategies.Your Path to Success: Key Outcomes in the First YearFirst 30 Days:Gain a comprehensive understanding of Evolv’s sensor ecosystem, datasets, and ML pipelines.Analyze dataset structure, labeling processes, and existing exploratory data analyses.Conduct initial UMAP/PCA/t-SNE analyses to visualize data distributions and detect anomalies.Spot opportunities to enhance data quality, labeling consistency, and dataset coverage.First 90 Days:Engage in deep representation analysis across sensor, time-series, and feature data.Evaluate classical ML and deep learning models by correlating model errors with data quality issues.Establish data quality metrics and initial dataset acceptance criteria.Collaborate with data collection teams to inform targeted data acquisition and relabeling efforts.Mine existing field data to recognize patterns and derive actionable insights.Devise methodologies to enhance data quality, transforming noisy or unverified data into clean, validated datasets.End of Year Goals:Own data-driven insights that lead to measurable improvements in ML model performance.Establish continuous monitoring for data drift, blind spots, and label quality.Offer strategic direction for future data collection, annotation, and curation.Create automated tools and dashboards for data quality reporting and representation analysis.Your Daily ResponsibilitiesData Understanding & Representation Analysis:Analyze high-dimensional sensor and feature data utilizing UMAP, t-SNE, PCA, and similar techniques.Identify clusters, outliers, distribution gaps, and blind spots within various classes and environments.Diagnose dataset shifts, domain mismatches, sparsity, and representation collapse.Model-Aware Data Analysis:Conduct data analyses that align with both classical ML models (XGBoost, SVR, k-NN, tree-based models) and deep learning frameworks (CNNs, Transformers).Investigate embeddings, confusion matrices, and failure cases to connect model issues back to data causes.Join Us at Evolv TechnologyAt Evolv Technology, we are dedicated to revolutionizing the way people experience spaces through intelligent sensor technology and advanced machine learning. We foster a collaborative environment where creativity and innovation thrive. Join us as we push the boundaries of technology to create safer and more efficient environments.

Mar 9, 2026
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company
Full-time|$152K/yr - $198K/yr|On-site|Waltham, Massachusetts, United States

Join Our TeamStep into a pivotal role at Evolv Technology as a Senior AI/Machine Learning Engineer, where you will spearhead innovations in AI-driven physical security solutions. As a vital member of our AI/ML team, you will design and implement cutting-edge machine learning and deep learning systems. Your expertise will be instrumental in harnessing various data sources, including magnetic sensors and 3D cameras, to develop real-time multi-sensor fusion solutions suitable for constrained hardware environments. This hands-on position demands profound knowledge in classical ML, deep learning, feature engineering, model optimization, and MLOps.In this role, you will not only build models but also enhance their accuracy and resilience, ensuring they perform reliably in real-world applications. This position is ideal for those who have a track record of making measurable improvements to machine learning models.

Mar 9, 2026
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companyAnduril Industries logo
Full-time|$220K/yr - $292K/yr|On-site|Waltham, Massachusetts, United States

Anduril Industries develops advanced defense technology for the United States and allied nations. The company blends experience from top technology companies with new methods for building military systems. Areas of focus include autonomy, artificial intelligence, computer vision, sensor fusion, and networking. Anduril’s products operate on Lattice OS, a platform that transforms large data streams into interactive 3D command and control centers. The research team designs algorithms and software that address scientific challenges with real-world impact. Projects move from concept to deployment, with research considered complete only when it is integrated into mission-critical systems for government and industry clients. Collaboration and practical results are core values for the team. Role overview Lead and mentor a small team by providing technical guidance and expertise. Develop mathematically sound solutions to complex information science problems. Prototype new algorithms as part of an agile software development cycle. Build high-performance software, ranging from tactical systems to web applications. Use modeling and simulation tools to demonstrate the effectiveness of new technology. Engage directly with clients to support their mission objectives. Communicate technical work and its impact clearly to both colleagues and clients. Location This Senior Research Scientist position is based in Waltham, Massachusetts, United States.

Apr 20, 2026
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companyZoomInfo logo
Full-time|$163.8K/yr - $257.4K/yr|Remote|Waltham, Massachusetts, United States

At ZoomInfo, we are dedicated to accelerating careers. Our fast-paced environment encourages bold thinking and empowers you to produce your best work. You will collaborate with passionate teammates who challenge one another and celebrate achievements together. With tools that enhance your contributions and a culture that supports your aspirations, you won’t just be part of the team—you’ll be instrumental in driving results. Principal Software Engineer, Applied AILocation: Remote or HybridTeam: Applied AILevel: PrincipalJoin Us in Reimagining B2B IntelligenceAt ZoomInfo, we are building the future of B2B marketing intelligence—and we’re seeking engineers who are eager to help shape that future.As a Principal Engineer on our Advertising, Company Intelligence, and Intent team, you will design and implement the fundamental systems powering our real-time marketing platform. From high-throughput advertising infrastructure to large-scale identity resolution and intelligent systems enhanced by LLMs, you will push the limits of scale, intelligence, and speed—delivering tangible business impact.Join a team engaged in a diverse array of ambitious, technically challenging projects—from APIs that process tens of billions of events daily to innovative buyer intent algorithms powered by LLMs, and a unified B2B identity graph. Based on your strengths and interests, you will be aligned with initiatives where you can make the most significant impact.This is a high-growth, high-ownership environment operating at the forefront of modern software engineering, data infrastructure, and applied AI.What You’ll DoDesign and build distributed systems capable of processing, enriching, and responding to billions of behavioral events in real-time.Develop high-performance APIs and services that support advertising, identity, and intent functionalities across the Marketing Platform.Utilize machine learning and large language models (LLMs) to analyze behavioral data, classify content, extract signals, and facilitate intelligent decision-making.Construct intelligent agents using frameworks like LangGraph or MCP to reason over data and power user-facing insights.Design and manage data pipelines employing tools such as Kafka, Kinesis, and ClickHouse to support both streaming and batch workloads.Ensure quality, performance, scalability, and observability across all systems you oversee.Collaborate cross-functionally with product managers, data scientists, and engineers to deliver customer-facing features.

Feb 4, 2026
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companyXometry logo
Full-time|$148K/yr - $193K/yr|On-site|Waltham, MA

At Xometry (NASDAQ: XMTR), we are at the forefront of innovation, connecting visionary thinkers with the manufacturers capable of transforming their ideas into reality. Our digital marketplace empowers manufacturers with essential resources for growth while enabling Fortune 1000 companies to seamlessly access global manufacturing capabilities.We are on the lookout for a Principal Software Engineer to spearhead the technical design and engineering of advanced systems aimed at predicting and resolving challenges in the manufacturing of our clients' parts. Your expertise will combine machine learning model predictions, part geometry data, and customer insights to enhance our ability to forecast manufacturing costs and identify suitable partners for successful part production. While previous experience in manufacturing or machine learning is beneficial, it is not a prerequisite.The successful candidate will bring at least 8 years of industry experience, with a minimum of 4 years in a technical leadership role within a dynamic, collaborative environment. This position requires a blend of technical leadership and hands-on contributions. Our teams thrive on collaboration, cross-functionality, and a rapid pace of innovation.

Feb 2, 2026
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companyBiocytogen Boston Corp logo
Full-time|On-site|Waltham, Massachusetts, United States

Biocytogen Boston Corp is on the lookout for a dynamic and skilled Pharmacology Scientist or Senior Scientist to enhance our preclinical research capabilities in both in vivo and in vitro settings. Our focus spans across immunology, immuno-oncology, metabolic diseases, and neurology. This position is perfect for individuals with extensive knowledge in pharmacological studies, disease model development, and cell-based assays who are excited about assessing innovative therapeutic agents for our clients.The right candidate will play a vital role in our growing CRO team, engaging in experimental work as well as strategic project management to support our biotech and pharmaceutical collaborators.Key ResponsibilitiesIn Vivo PharmacologyDesign and create animal models, conducting in vivo experiments to assess the biological effectiveness of new therapeutic compounds.Lead in vivo service projects and preclinical studies, serving as Project Manager or Study Director.Conduct animal handling, tumor inoculation, drug administration via various routes, blood and tissue collection, tumor measurements, and PK/PD studies.Develop and execute internal model-building projects while characterizing diverse humanized mouse models.Provide troubleshooting support and technical mentorship to junior team members.Work closely with the BD/Sales team to strategize client project planning and technical discussions.Deliver presentations of project outcomes to clients and internal stakeholders; draft comprehensive scientific reports and summaries.Guide and support the development of junior research associates.In Vitro and Ex Vivo PharmacologyIndependently establish, validate, and execute a wide variety of in vitro and ex vivo assays, which include:Immune cell profiling from blood and tissues.Functional assays utilizing primary cells (T cells, NK cells, macrophages).Cytokine profiling, cytotoxicity, and apoptosis assays.Innovate new assay technologies by reviewing scientific literature and adapting methodologies from partnerships and internal collaborations.Perform flow cytometry (FACS), ELISA, Western blot, qRT-PCR, and multiplex cytokine analyses.Contribute to the design and execution of in vivo pharmacology studies from an in vitro perspective.Present research results in internal meetings and contribute to external scientific discussions.

Dec 22, 2025
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companyBiocytogen logo
Full-time|On-site|Waltham, Massachusetts, United States

Join the innovative team at Biocytogen, where we are dedicated to advancing the field of antibody drug development. We are actively seeking talented and driven scientists to enhance our antibody discovery team. This pivotal role focuses on optimizing therapeutic antibody binders derived from our cutting-edge RenBiologics program, which boasts a comprehensive library of therapeutic antibodies targeting a vast array of druggable genes. The ideal candidate will apply state-of-the-art antibody engineering methods to enhance binding affinity, specificity, stability, and therapeutic efficacy. Your contributions will play a vital role in the development of antibodies across multiple therapeutic domains, including immuno-oncology, inflammatory and autoimmune disorders, neurology, cardiovascular diseases, and metabolic conditions.

Jan 9, 2026
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companyOruka Therapeutics logo
Full-time|$130K/yr - $208K/yr|Hybrid|Waltham, Massachusetts, United States

About Oruka Therapeutics Oruka Therapeutics (Nasdaq: ORKA) develops biologics for chronic skin conditions. The company’s mission centers on helping patients with diseases like plaque psoriasis achieve lasting relief, aiming for high rates of disease clearance with infrequent dosing, sometimes just once or twice a year. Oruka’s portfolio features proprietary antibodies from Paragon Therapeutics that target the underlying mechanisms of plaque psoriasis and other dermatologic or inflammatory disorders. More information is available at www.orukatx.com. Role Overview: Scientist/Senior Scientist, Upstream Process Development & Manufacturing (Biologics) Oruka Therapeutics is hiring a Scientist or Senior Scientist to support upstream manufacturing operations in Waltham, Massachusetts. This position focuses on process development and the delivery of clinical trial materials produced at Contract Development and Manufacturing Organizations (CDMOs). The role works closely with the CMC team and collaborates with colleagues in downstream processing, analytical development, drug product, Quality Assurance, regulatory affairs, and program management. This position contributes to CMC strategy and supports the development of biotherapeutics in an innovative and growing team environment.

Apr 17, 2026
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companyArtech Information Systems LLC logo
Scientist II - Innovative Research Role

Artech Information Systems LLC

Contract|On-site|Waltham

Join our dynamic team at Artech Information Systems LLC as a Scientist II, where your expertise will contribute to cutting-edge research and innovation. We are seeking a detail-oriented and motivated individual to engage in scientific projects that push the boundaries of technology and discovery.

Jan 25, 2016
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companyArtech Information Systems LLC logo
Scientist II

Artech Information Systems LLC

Contract|On-site|Waltham

Join Artech Information Systems LLC as a Scientist II, where you will play a pivotal role in advancing our innovative solutions. As a mid-senior level scientist, you will be involved in cutting-edge research and development projects, utilizing your expertise to drive results and contribute to our team's success.

Jan 26, 2016
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companyXometry logo
Full-time|$160K/yr - $180K/yr|On-site|Waltham, MA

Xometry (NASDAQ: XMTR) connects problem-solvers with manufacturers to bring new ideas to market. The company’s digital marketplace offers manufacturers growth tools and gives buyers, including Fortune 1000 firms, access to global production resources. Role overview The Senior Staff Software Engineer will join the core machine learning and data platform engineering team in Waltham, MA. This group builds and maintains the infrastructure behind Xometry’s AI and ML solutions, such as the Instant Quoting Engine®, Computational Geometry Service, and other data-driven products that support the marketplace. What you will do Collaborate with AI leadership to strengthen and expand the core infrastructure for AI and ML initiatives Deliver essential components that power the Xometry ecosystem, focusing on hands-on engineering Support and improve data products that drive marketplace operations Take ownership of projects and contribute to ongoing platform development Encourage innovation and help shape the future of Xometry’s technology Location This role is based in Waltham, MA.

Apr 20, 2026
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companyArtech Information Systems LLC logo
Scientist II

Artech Information Systems LLC

Contract|On-site|Waltham

We are seeking a highly skilled and motivated Scientist II to join our dynamic team. In this role, you will leverage your expertise to contribute to innovative research and development projects. The ideal candidate will possess a strong background in scientific methodologies and a passion for advancing knowledge in their field.

Jan 18, 2016
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companyArtech Information Systems LLC logo
Scientist I

Artech Information Systems LLC

Contract|On-site|Waltham

Join Artech Information Systems LLC as a Scientist I, where you will embark on a scientific journey in a dynamic and supportive environment. This entry-level position is an excellent opportunity for recent graduates or those new to the field of science to apply their knowledge and skills in a practical setting. You will engage in research, data analysis, and collaboration with seasoned professionals, contributing to innovative projects that make a difference.

Apr 22, 2016
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company
Full-time|$129K/yr - $209K/yr|On-site|Waltham, Massachusetts, United States

Join Our TeamWe invite you to become a vital part of Evolv as a Senior Data Infrastructure Engineer within our Machine Learning & Sensors organization. This pivotal role entails the design, construction, and maintenance of robust, secure, and scalable data pipelines that drive our AI/ML research and production systems. You will take charge of the complete data lifecycle—from ingestion across thousands to millions of edge devices, through cloud processing, to a centralized data factory that supports model training, evaluation, and ongoing enhancement.Data is at the core of our mission to revolutionize AI-based weapon detection systems. Your expertise will ensure seamless data flow across various geographies, devices, and cloud systems, while adhering to stringent standards for quality, privacy, security, and scalability. This position is perfect for someone who is passionate about the intersection of distributed systems, cloud pipelines, and ML-driven data requirements.Success in the Role: Your First YearIn the first 30 days:Gain an in-depth understanding of our existing edge-to-cloud data pipelines and deployment environments.Evaluate current data ingestion processes, governance frameworks, and cloud infrastructure.Identify challenges related to data reliability, quality, and operational scalability.Establish rapport with AI/ML, data science, field operations, and cloud engineering teams.Design and prototype both cloud and edge data processing pipelines.Within the first three months:Implement enhancements to critical ingestion, validation, and processing pipelines.Deploy scalable data pipelines using AWS components such as S3, EC2, Lambda, Glue, Step Functions, and SageMaker integrations.Develop automated validation workflows to identify data corruption, missing metadata, or malformed data.Create automated model evaluation, training, and improvement pipelines to accelerate experimentation.Collaborate with field operations to enhance data reliability, observability, and coverage.By the end of the first year:Oversee the entire lifecycle of mission-critical data pipelines that support AI/ML research and production.Architect advanced edge-to-cloud data systems capable of scaling across millions of devices.Establish and enforce data governance frameworks, including retention, access control, privacy, and lineage.Enable ML teams to quickly conduct experiments with high-quality, discoverable, versioned datasets.

Mar 9, 2026
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company
Full-time|On-site|Waltham, MA

Crescent Biopharma is committed to revolutionizing oncology through the development of innovative therapies for cancer patients. Our robust clinical-stage pipeline includes a flagship PD-1 x VEGF bispecific antibody and cutting-edge antibody-drug conjugates. By harnessing diverse modalities and well-established targets, we strive to expedite the delivery of potentially groundbreaking treatments, whether as standalone therapies or in synergistic combination regimens for various solid tumors. To learn more, visit www.crescentbiopharma.com and connect with us on LinkedIn and Twitter.The Senior Scientist in Toxicology will spearhead the design, leadership, and execution of nonclinical safety strategies integral to Crescent's research and development initiatives. Reporting directly to the Senior Director of Toxicology, this role demands expertise in the comprehensive design and implementation of toxicology studies, ensuring the safety and efficacy of our innovative therapies.

Feb 6, 2026

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