Senior Manager of Clinical Data Management

As a Senior Manager of Clinical Data Management at Deciphera Pharmaceuticals, you will lead and oversee the clinical data management function, ensuring high-quality data collection and management practices. You will play a pivotal role in supporting clinical trials through the oversight of data management processes, and collaborate with cross-functional team…

Role Overview Crescent Biopharma is seeking a Senior Manager or Associate Director of Clinical Data Management based in Waltham, MA. This position leads data management activities for clinical trials, guiding teams to uphold data integrity and meet regulatory requirements. What You Will Do Direct and oversee data management operations for clinical studies. Ensure all processes align with regulatory standards and internal protocols. Work closely with cross-functional partners to improve data collection and analysis methods. Support the development of new therapies by maintaining high-quality clinical data. What Crescent Biopharma Looks For Strategic mindset with strong leadership abilities. Experience managing data in clinical trial settings. Commitment to data accuracy and regulatory compliance. Effective collaboration with diverse project teams.

About Us:Oruka Therapeutics (Nasdaq: ORKA) is at the forefront of developing innovative biologics that aim to revolutionize the treatment of chronic skin diseases. Our mission is to empower patients suffering from conditions like plaque psoriasis with unprecedented freedom from their ailments by achieving complete disease clearance with treatment regimens as infrequent as once or twice a year. We are advancing a proprietary portfolio of potentially best-in-class antibodies, engineered by Paragon Therapeutics, targeting the fundamental mechanisms behind plaque psoriasis and other dermatological and inflammatory disorders. For more detailed information, please visit www.orukatx.com.As we cultivate our core team, we are in search of exceptional talent across various functional areas—individuals who are not merely seeking a job but are enthusiastic about being part of a larger vision. We seek those who are passionate about making a meaningful impact and are eager to contribute to fostering an engaged, inclusive, and positive company culture.Role Overview:The Clinical Trial Manager/Senior Clinical Trial Manager will be responsible for ensuring compliance with trial protocols, regulatory requirements, and overall trial execution.

Role Overview:The Senior Clinical Project Manager is responsible for steering and overseeing intricate clinical trials, showcasing extensive expertise in clinical operations methodologies. This position requires exemplary organizational and leadership skills, coupled with strategic acumen. The individual will provide operational guidance, supervision, and excellence in execution to guarantee the timely, budget-compliant, and regulatory-compliant delivery of clinical studies, adhering to GCP, ICH, and FDA standards. The Senior Clinical Project Manager collaborates across departments to align study goals with program objectives while driving process enhancement initiatives within a dynamic small-to-midsize biotech setting.Key Responsibilities:Clinical Trial Leadership & Execution (40%)Direct the planning, execution, and successful delivery of clinical trials within established quality, time, and budget constraints. Supervise cross-functional team (CFT) performance, ensuring operational alignment with Clinical Operations objectives, while concurrently managing multiple studies.Cross-Functional Team Management (25%)Lead and mentor cross-functional study teams (CFTs), promoting collaboration, accountability, and problem-solving across various functions. Delegate responsibilities effectively to support staff as necessary.Vendor & CRO Oversight (15%)Manage discussions and negotiations with CROs and vendors to ensure compliance with contractual obligations, budget constraints, and study timelines. Actively identify and mitigate operational risks to guarantee high-quality outputs.Process Optimization & Strategic Execution (10%)Assess current methodologies and pinpoint opportunities for enhanced efficiency and effectiveness across clinical operations processes and systems.Stakeholder Communication & Engagement (10%)Update internal stakeholders on study progress, challenges, and outcomes, ensuring transparency and alignment with program leadership and clinical operations management.Other duties and responsibilities as assigned.

About Us:Oruka Therapeutics (Nasdaq: ORKA) is pioneering innovative biologics aimed at redefining the treatment landscape for chronic skin conditions. Our mission is to provide individuals afflicted by chronic skin diseases, such as plaque psoriasis, with unparalleled freedom from their ailments through therapies that may require administration only once or twice annually. We are advancing a unique portfolio of potentially leading antibodies, engineered by Paragon Therapeutics, that target the fundamental mechanisms of plaque psoriasis and other dermatologic and inflammatory conditions. To learn more, please visit www.orukatx.com.As we expand our core team, we are on the lookout for exceptional talent across various functional areas. We seek individuals who are not only searching for employment but also aspire to be part of a transformative mission. If you are passionate about making a meaningful impact and are eager to help cultivate a vibrant, inclusive, and positive organizational culture, we encourage you to apply.Job Title: Senior Clinical Trial ManagerLocation: Hybrid – Waltham, MA. Candidates are expected to work in the office 3 days per week.Role Overview:The Senior Clinical Trial Manager will act as the clinical functional lead, spearheading clinical trial initiatives for Oruka's innovative dermatological treatments. You will be responsible for ensuring compliance with trial protocols, regulatory standards, and operational efficiency while collaborating with cross-functional teams to propel Oruka's clinical pipeline forward. A Senior Clinical Trial Manager is expected to manage the clinical trial independently, effectively planning and executing the study to guarantee the quality of deliverables within the specified budget and timeline.Key Responsibilities:Clinical Trial Management:Lead and oversee multiple clinical trials from initiation through completion, ensuring compliance with study timelines and financial parameters.Collaborate with investigators, vendors, and cross-functional teams to assure excellent study execution and operational performance.Supervise the preparation and review of trial-related documentation, including protocols, informed consent forms (ICFs), case report forms (CRFs), and study reports.

Deciphera Pharmaceuticals, Inc. is hiring a Senior Manager, Clinical Quality Assurance in Waltham. This position leads the Clinical Quality Assurance team and plays a central role in maintaining high standards for clinical trial quality and regulatory compliance. Role Overview The Senior Manager, Clinical Quality Assurance develops and implements quality assurance strategies for clinical programs. The role involves oversight of compliance with regulatory requirements and internal quality expectations throughout all phases of clinical trials. Key Responsibilities Lead the Clinical Quality Assurance team Develop and execute quality assurance strategies for clinical trials Conduct audits to assess compliance with regulatory standards Ensure all clinical trial activities meet regulatory and company quality requirements What We’re Looking For Extensive experience in clinical quality assurance Strong knowledge of regulatory requirements for clinical trials Proven ability to develop and implement quality assurance processes Experience conducting audits in a clinical setting

Oruka Therapeutics develops biologic treatments for chronic skin conditions, including plaque psoriasis. The company’s approach centers on infrequent dosing and proprietary antibodies designed to address dermatologic and inflammatory disorders. Oruka is headquartered in Waltham, Massachusetts, and operates as a publicly traded company (Nasdaq: ORKA). Role overview The Senior Manager, Clinical Supply Chain (Biologics) leads supply chain operations for clinical trials spanning early to late development stages. This hybrid role is based in Waltham, MA, with an on-site presence required three days per week. The position reports to the head of Clinical Supply Chain and supports multiple trials in the US, Canada, and the EU. Key responsibilities include managing labeling, packaging, distribution, inventory, forecasting, and handling supply expiration. The Senior Manager also oversees IRT (Interactive Response Technology) initiation and maintenance. Collaboration with CMC, Clinical, Program Management, Regulatory, and Quality teams is central to the work, as is helping to establish supply chain best practices and processes. The scope covers global activities, with particular attention to supplies such as vials and pre-filled syringes. Key responsibilities Carry out clinical supply chain tasks, including labeling, packaging, and inventory management. Oversee distribution, forecasting, and supply expiration for clinical trials. Initiate and maintain IRT systems to support trial operations. Work closely with cross-functional teams to ensure alignment and compliance. Support development and implementation of supply chain processes and best practices. Requirements Experience managing clinical supply chain operations for biologics, ideally across multiple regions. Strong communication skills and a results-oriented approach. Ability to work effectively with cross-functional teams and external partners. Familiarity with clinical trial supply needs, especially for vials and pre-filled syringes. Hybrid work schedule: in-office presence in Waltham, MA, three days per week. For more about Oruka Therapeutics, visit www.orukatx.com.

Join our team as a Clinical Project Manager at Deciphera Pharmaceuticals, where you will play a critical role in steering the planning, execution, and successful delivery of clinical trials. This position involves managing small to mid-sized studies while also supporting larger, more complex programs by effectively coordinating cross-functional teams and external partners. Your leadership will ensure trials are completed on schedule, within budget, and meet the highest quality standards.Key Responsibilities:Drive successful clinical trial delivery by supporting cross-functional study execution teams.Provide strategic oversight and address operational challenges and risks proactively.Manage study timelines, resources, and deliverables to meet quality, cost, and scheduling expectations.Oversee the performance of CROs and external vendors to ensure compliance with contractual and operational requirements.Support study feasibility, including patient enrollment strategies, site selection, and data collection planning.Contribute to protocol development and ensure alignment with program objectives during study execution.Implement effective risk mitigation strategies to enhance trial outcomes.

At ZoomInfo, we believe in accelerating careers through innovation and collaboration. We operate with agility, challenge conventional thinking, and empower you to produce exceptional work. You will join a team that values support, challenges norms, and celebrates collective achievements. With the right tools and a culture that nurtures your ambitions, you will not just contribute; you will drive impactful change swiftly.The Opportunity:ZoomInfo has established the most advanced Go-To-Market (GTM) data acquisition infrastructure in the industry. We are now applying that same meticulous approach to the field of context engineering—an emerging discipline that determines whether AI systems yield transformative value or merely incremental enhancements.This role is pivotal in architecting the context layer that powers our AI intelligence across products such as Copilot, GTM Studio, and MarketingOS. You will revolutionize how ZoomInfo's agentic workflows access, compress, and deliver precise information at critical moments. Your work will have a profound impact across the organization: every AI interaction, every intelligent recommendation, and every autonomous agent action will rely on the context infrastructure you develop.As we transition to an AI-first product approach across the company, the context pipelines are still in their infancy, offering a unique opportunity to establish architectural standards and platform practices that will enhance value for multiple product teams in the coming years.What You'll Do:Design Context Acquisition Pipelines: You will create and optimize the methods by which ZoomInfo retrieves, transforms, and delivers context from our semantic data layer, memory systems, and various data sources. Your focus will be on balancing retrieval quality with latency and cost, utilizing hybrid search strategies, intelligent caching, and context compression techniques that maintain information density while adhering to token budgets.Manage the Context Layer Platform: You will build infrastructure that serves multiple product teams—Copilot, GTM Studio, MarketingOS—as internal clients. You will set API standards, enhance developer experiences, and establish integration patterns that expedite feature delivery. You will maintain a delicate balance between providing flexible building blocks and crafting opinionated solutions that integrate best practices.Implement Quality Through Measurement: You will develop evaluation frameworks utilizing RAGAS metrics and custom benchmarks. You will monitor retrieval accuracy, context relevance, hallucination rates, and system performance in production. You will translate quality signals into architectural enhancements, collaborating closely with machine learning engineers.

About Oruka Therapeutics Oruka Therapeutics (Nasdaq: ORKA) develops biologic therapies for chronic skin conditions. The company focuses on giving patients with diseases like plaque psoriasis greater freedom through infrequent dosing, just once or twice a year. Oruka’s pipeline features proprietary antibodies from Paragon Therapeutics, designed to address the underlying mechanisms of plaque psoriasis and other dermatologic or inflammatory disorders. Learn more at www.orukatx.com. Position Details Title: Clinical Scientist, Clinical Development (Multiple openings) Location: Hybrid (Waltham, MA) with an expectation of three days per week in the office. Remote candidates will also be considered. Role Overview The Clinical Scientist plays a key role in planning and executing clinical trials. This position supports the development of study protocols, assists with implementation, reviews clinical data, and helps prepare documentation to meet clinical development goals. The Clinical Scientist works closely with cross-functional teams and reports directly to the Medical Director of Clinical Development to help deliver high-quality clinical data. Main Responsibilities Clinical Trial Design and Oversight: Help develop clinical trial protocols, including patient selection criteria, study endpoints, and data collection methods. Monitor clinical trial data at study sites to ensure adherence to protocols and Good Clinical Practice (GCP) standards.

Deciphera Pharmaceuticals is seeking a highly skilled and experienced Senior Medical Director of Clinical Development to lead our clinical research initiatives. In this pivotal role, you will oversee the design and execution of clinical trials and collaborate closely with cross-functional teams to advance our innovative therapies. The ideal candidate will have a deep understanding of clinical development processes and a proven track record in leading successful trials.

About Us:At Oruka Therapeutics (Nasdaq: ORKA), we are pioneering innovative biologics aimed at transforming the treatment landscape for chronic skin disorders. Our mission is to empower individuals battling chronic skin conditions, such as plaque psoriasis, by providing them with the utmost freedom from their ailments, achieving significant disease clearance through infrequent dosing, potentially just once or twice yearly. Our proprietary collection of antibodies, meticulously crafted by Paragon Therapeutics, targets the fundamental mechanisms of plaque psoriasis and other dermatological and inflammatory conditions. To learn more, visit www.orukatx.com.As we expand our core team, we are on the lookout for exceptional talent across various functional areas—individuals who seek more than just employment, but rather a chance to be part of something transformative. We value passion for making a difference and contributions to fostering an engaged, inclusive, and positive workplace culture.Job Title: Director of Clinical Quality AssuranceLocation: Remote; candidates located in the Waltham, MA area are preferred.Role Overview:The Director of Clinical Quality Assurance will provide strategic leadership and oversight for Oruka's clinical development initiatives, focusing primarily on Good Clinical Practice (GCP) and associated quality systems that support clinical trials. This role will establish, enhance, and oversee clinical quality processes appropriate to each phase, ensuring comprehensive supervision of clinical trial execution and vendor performance while preparing for global health authority inspections, including FDA Bioresearch Monitoring (BIMO) inspections.This position will collaborate closely with Clinical Operations, Clinical Development, Biometrics, Pharmacovigilance, Regulatory Affairs, Medical Writing, and external service providers to ensure compliance with GCP, relevant global regulations, internal procedures, and protocol requirements throughout the clinical trial lifecycle. The Director of Clinical QA will proactively contribute quality insights, support continuous improvement initiatives, and help cultivate a quality-centric culture as the organization progresses with its pipeline.Key Responsibilities:Clinical Quality Oversight: Ensure compliance with GCP and applicable regulatory requirements for new and ongoing clinical studies.

About Oruka Therapeutics Oruka Therapeutics (Nasdaq: ORKA) develops biologic therapies for chronic skin diseases, with a focus on achieving complete disease clearance for patients with conditions like plaque psoriasis. The company’s antibody portfolio, created in partnership with Paragon Therapeutics, targets the underlying mechanisms of dermatologic and inflammatory diseases. Oruka’s goal is to offer patients long-lasting relief, potentially with just one or two treatments per year. Learn more at www.orukatx.com. Position Details Title: Director/Senior Medical Director, Clinical Development (Multiple openings) Location: Remote or hybrid. For those near Waltham, MA or Menlo Park, CA, hybrid work is available (3 days per week in office). Role Overview The Director or Senior Medical Director, Clinical Development, leads and supports clinical trials across Oruka’s pipeline. This role shapes clinical study design, oversees trial execution, and interprets data to validate product safety and efficacy. Collaboration with internal teams and external partners is central, ensuring clinical activities align with regulatory, scientific, and business goals. Main Responsibilities Clinical Trial Design and Oversight: Help develop clinical trial protocols, including patient selection, study endpoints, and data collection plans. Oversee the conduct of clinical trials at study sites, ensuring adherence to protocols and Good Clinical Practice (GCP) standards. Review and interpret trial data to evaluate the safety and efficacy of investigational products.

Join Our TeamWe invite you to become a vital part of Evolv as a Senior Data Infrastructure Engineer within our Machine Learning & Sensors organization. This pivotal role entails the design, construction, and maintenance of robust, secure, and scalable data pipelines that drive our AI/ML research and production systems. You will take charge of the complete data lifecycle—from ingestion across thousands to millions of edge devices, through cloud processing, to a centralized data factory that supports model training, evaluation, and ongoing enhancement.Data is at the core of our mission to revolutionize AI-based weapon detection systems. Your expertise will ensure seamless data flow across various geographies, devices, and cloud systems, while adhering to stringent standards for quality, privacy, security, and scalability. This position is perfect for someone who is passionate about the intersection of distributed systems, cloud pipelines, and ML-driven data requirements.Success in the Role: Your First YearIn the first 30 days:Gain an in-depth understanding of our existing edge-to-cloud data pipelines and deployment environments.Evaluate current data ingestion processes, governance frameworks, and cloud infrastructure.Identify challenges related to data reliability, quality, and operational scalability.Establish rapport with AI/ML, data science, field operations, and cloud engineering teams.Design and prototype both cloud and edge data processing pipelines.Within the first three months:Implement enhancements to critical ingestion, validation, and processing pipelines.Deploy scalable data pipelines using AWS components such as S3, EC2, Lambda, Glue, Step Functions, and SageMaker integrations.Develop automated validation workflows to identify data corruption, missing metadata, or malformed data.Create automated model evaluation, training, and improvement pipelines to accelerate experimentation.Collaborate with field operations to enhance data reliability, observability, and coverage.By the end of the first year:Oversee the entire lifecycle of mission-critical data pipelines that support AI/ML research and production.Architect advanced edge-to-cloud data systems capable of scaling across millions of devices.Establish and enforce data governance frameworks, including retention, access control, privacy, and lineage.Enable ML teams to quickly conduct experiments with high-quality, discoverable, versioned datasets.

At ZoomInfo, we are committed to accelerating careers. We operate with agility, embrace bold ideas, and empower you to achieve your best work. You’ll be part of a team that values deeply caring connections, challenges conventional thinking, and celebrates every success. Our innovative tools enhance your impact, and our culture fosters your ambitions, ensuring you don’t just participate but drive meaningful results at a rapid pace.As a Senior Partnerships Manager, you will play a pivotal role within the ZoomInfo Partnerships Organization, leading the design, implementation, and management of programs that establish a top-tier partner ecosystem aligned with our strategic goals. Your responsibilities will include building and overseeing multiple partner initiatives across various sectors, including Channel Sales, Technology, and Solutions, as we swiftly expand our Partner Ecosystem. We seek a proactive individual who thrives in ambiguity, possesses an entrepreneurial spirit, yet can collaborate effectively within a larger team structure. You will leverage data analysis and qualitative insights to inform your recommendations and are eager to explore innovative solutions. Your proven ability to manage projects end-to-end while engaging with diverse stakeholders will be crucial for delivering outstanding results in a fast-paced, dynamic environment. This position reports directly to the SVP of Partnerships, ensuring that our partner initiatives align with ZoomInfo’s overarching corporate strategy.

Anduril Industries is a pioneering defense technology firm dedicated to enhancing the military capabilities of the U.S. and its allies through innovative technology solutions. By integrating the expertise and business models of the most forward-thinking companies in the 21st century, Anduril is redefining the design, production, and sales processes of military systems. Our suite of products is powered by Lattice OS, an advanced AI-driven operating system that consolidates extensive data streams into a dynamic, 3D command and control center. As we navigate a new era of strategic competition, Anduril is dedicated to delivering breakthrough advancements in autonomy, AI, computer vision, sensor fusion, and networking technology to military operations within months instead of years.ABOUT THE TEAMThe Anduril Imaging team is at the forefront of developing cutting-edge imaging systems, both in hardware and software, designed to address the most pressing security challenges faced by America and its allies. Our team leverages computer vision, perception, electro-optical, infrared, and sensor data to provide our warfighters and allies with a competitive advantage.ABOUT THE JOBThe Senior Production Manager role is a blend of technical expertise and leadership, placing you at the helm of team development and daily operational management for our intricate hardware platforms. Success in this crucial role requires a consistent track record in team management, operational excellence, and achieving financial objectives, ensuring the delivery of mission-critical products of the highest quality.WHAT YOU’LL DOLead Production Operations: Supervise the production of a specific product line, guiding a team of skilled technicians to ensure efficient production and timely delivery of imaging hardware.Drive Daily Production Goals: Strategically plan production schedules to achieve desired performance outcomes while tactically directing daily operations to meet on-time delivery targets.Champion Quality & Safety: Uphold quality and safety standards to minimize defects and promote a secure working environment.Develop & Mentor Talent: Actively coach, mentor, and support production technicians, encouraging professional development and cross-training within the team.

Xometry (NASDAQ: XMTR) is at the forefront of transforming industries by bridging innovative minds with manufacturers capable of realizing their visions. Our cutting-edge digital marketplace equips manufacturers with essential resources to expand their businesses, while enabling Fortune 1000 buyers to leverage global manufacturing capabilities effortlessly.We are seeking a dynamic Senior Category Manager based in Boston, Maryland, DC, or Northern Virginia to strategically drive the growth of our Additive business. In this role, you will define and implement comprehensive category strategies, tackle complex challenges, execute tactical initiatives, and monitor key performance indicators. Successful Category Managers will possess exceptional negotiation skills and excel in cross-functional project management.

Role Overview:The Director of Clinical Operations plays a pivotal role in ensuring that clinical stage programs meet both strategic and operational objectives in compliance with set timelines, budgets, and quality standards. This leadership position is vital in guiding the Clinical Operations team, shaping clinical program strategies, and fostering collaboration and transparency across multiple functions. The Director will work closely with both internal stakeholders and external partners to facilitate high-quality clinical trial execution within the dynamic landscape of a small-to-midsize biotech organization.Key Responsibilities:Program Strategy & Leadership (35%)Formulate and implement clinical program strategies that are aligned with corporate objectives. Lead the Clinical Operations team to optimize the allocation of resources across various programs.Clinical Trial Oversight (25%)Ensure that clinical trials are meticulously defined, planned, and executed in accordance with GCP, ICH, and FDA regulations. Monitor study timelines, budgets, and quality metrics to drive operational excellence.Regulatory & Documentation Support (15%)Assist in drafting key regulatory documents, ensuring that clinical program outputs meet submission requirements and regulatory standards.Vendor & CRO Management (15%)Oversee and manage Contract Research Organizations (CROs), vendors, and external partners to ensure that performance, deliverables, and financial accountability align with expectations.Team Development & Collaboration (10%)Cultivate a collaborative environment within Clinical Operations and exemplify leadership values. Encourage transparent communication, accountability, and operational discipline across the department.Other duties as assigned.

About Us: Cogent Biosciences is a publicly traded biotechnology company dedicated to pioneering innovative precision therapies for patients with significant unmet medical needs. Our flagship program, bezuclastinib, is engineered to effectively target and inhibit exon 17 mutations prevalent in the KIT receptor tyrosine kinase, notably including KIT D816V, which plays a critical role in the rare and severe condition known as Systemic Mastocytosis. Furthermore, these mutations are also implicated in gastrointestinal stromal tumors (GIST), a cancer type highly reliant on oncogenic KIT signaling. Bezuclastinib has demonstrated encouraging preliminary data across all three trials: APEX for AdvSM, SUMMIT for NonAdvSM, and PEAK for GIST, showcasing a favorable safety profile in over 600 patients both as a standalone treatment and in combination therapies. Position Overview: As the Senior Manager of Trade and Distribution, you will oversee the management of our Specialty Distributor network. Your primary responsibility will be to facilitate the physical and financial flow of Cogent Biosciences’ portfolio, starting with the launch of Bezuclastinib. This role requires maintaining robust relationships with Specialty Distributor customers, driving business growth for Cogent Biosciences, and actively contributing to the evolving channel strategy. You will manage all business operations for assigned customers, including inventory control, product fulfillment, data management, and return operations. Reporting directly to the Executive Director of Trade & Distribution within the Market Access team, you will collaborate closely with Corporate Accounts, Payer Accounts, Field Sales, Patient Access Services, and Commercial Operations, along with other internal colleagues at Cogent Biosciences. Key Responsibilities: Strategic Relationship Management: Act as the primary liaison for five core specialty distributors, conducting quarterly business reviews, negotiating service agreements, and ensuring contract compliance. Sustaining Long-term Partnerships: Develop and nurture enduring customer relationships with assigned accounts through a comprehensive understanding of their organization, structure, business strategy, and priorities. Business Operations Oversight: Manage all aspects of operations including inventory, order fulfillment, data management, and returns.

Role overview Allego seeks a Senior Engineering Manager to lead an engineering team in Waltham, Massachusetts. This role involves managing projects from initial planning through to final delivery, with a strong emphasis on meeting the company’s quality standards. The team’s work centers on building solutions that help Allego’s clients achieve their goals. What you will do Guide and support engineers throughout each stage of project development Mentor team members, encouraging both professional growth and skill advancement Collaborate with cross-functional partners to ensure timely product delivery Keep engineering work focused on high-quality outcomes