About the job
Zenas is at the forefront of biopharmaceutical innovation, dedicated to transforming the lives of patients with autoimmune diseases. Our strategy fuses the expertise of our seasoned leadership team with a meticulous process for sourcing and developing product candidates that promise enhanced clinical outcomes for those affected by these conditions. Currently, we are progressing two late-stage flagship molecules: obexelimab and orelabrutinib. Obexelimab, our lead candidate, is a bifunctional monoclonal antibody crafted to target both CD19 and FcγRIIb, effectively modulating B cell lineage activity linked to various autoimmune diseases, all while preserving cell integrity. We believe that the unique mechanism of obexelimab, combined with its self-administered subcutaneous delivery, positions it as a transformative solution for chronic autoimmune conditions. Orelabrutinib, on the other hand, is a promising, highly selective oral small molecule Bruton’s Tyrosine Kinase (BTK) inhibitor, designed to tackle compartmentalized inflammation and disease progression in Multiple Sclerosis (MS). Additionally, our early-stage programs feature a preclinical oral IL-17AA/AF inhibitor and a brain-penetrant TYK2 inhibitor, both demonstrating potential for best-in-class status.
We are eager to attract exceptional talent who share our passion for patient care and possess a proven track record in global product acquisition, development, and commercialization. At Zenas, our colleagues thrive in a dynamic learning environment where both personal and organizational accomplishments flourish as we strive to establish ourselves as a leader in immunology and autoimmune disease treatment, driven by our core values of Transparency, Relationships, Urgency, Excellence, and true Innovation!
Position Summary:
The Head of Biostatistics will assume a pivotal leadership role within the Biostatistics function, spearheading statistical strategy and oversight for all clinical programs and studies. This individual will manage and mentor the biostatistics and statistical programming team, collaborating closely with cross-functional departments such as clinical development, clinical operations, clinical pharmacology, pharmacovigilance, regulatory affairs, and project management to ensure alignment of statistical elements with the overarching program strategy. Furthermore, the Head of Biostatistics will engage with regulatory bodies and oversee the preparation of statistical components for protocols, clinical study reports, and regulatory submissions.