About the job
Eikon Therapeutics is an innovative biopharmaceutical company leveraging cutting-edge technology at the nexus of chemistry, engineering, computation, and biology to develop groundbreaking therapies for critical diseases. Our discovery platform, founded on pioneering advancements by our Nobel Prize-winning founders (2014), has led to the creation of advanced microscopes that allow for real-time, molecular-resolution tracking of protein dynamics in living cells, thus revealing new potential drug targets.
Position Overview
We are in search of a proactive Scientist II focused on Cell Line Engineering and CRISPR Screening, possessing robust experience in cell line engineering, CRISPR screening techniques, and data interpretation to bolster our drug discovery initiatives. The selected candidate will play a vital role in target validation and functional genomics to expedite the creation of innovative therapeutics.
About You
You are an inquisitive and systematic scientist who excels at transforming intricate challenges into straightforward, testable hypotheses. You exhibit a strong sense of ownership, thoroughness, and integrity in your work, complemented by a collaborative spirit and a genuine appreciation for teamwork across various functions.
Your Responsibilities
- Develop and validate intricate mammalian cell line models (including gene knock-in) customized for target identification and drug screening, utilizing Landing Pad, CRISPR/Cas9, and lentiviral methodologies.
- Design and perform pooled and arrayed CRISPR knockout and activation screens in relevant disease models. Expertise in CRISPR/Cas9 gene editing, encompassing sgRNA design, lentiviral packaging, transduction, and validation of knockout, knock-in, or gene activation constructs.