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Experience
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Key ResponsibilitiesFacilitate the management of large-scale biobank datasets in Polaris, our internal platform, by creating scalable data ingestion, cleaning, processing, and validation pipelines. Collaborate with scientific computing teams to design and implement machine learning models that support workflows in research and small molecule drug discovery, including compound property prediction and data analysis.
About the job
Maze Therapeutics applies precision medicine to address both common and rare diseases. The Machine Learning Application Engineer II role is based in South San Francisco and focuses on building and improving production-ready solutions that advance drug discovery efforts.
Role overview
This position centers on designing and developing data and machine learning infrastructure that supports different stages of drug discovery, from early research through lead optimization and development. The work involves refining existing systems to improve reliability and scalability while ensuring alignment with scientific objectives.
What you will do
Design and develop infrastructure for data and machine learning to support multiple phases of drug discovery.
Enhance current systems to improve reliability, scalability, and scientific relevance.
Apply FAIR data principles to maintain strong standards in data management and engineering.
Collaborate with scientific and engineering teams to deliver solutions that enable data-driven research.
Reporting structure
This role reports to a Senior Data Engineer.
About Maze Therapeutics
Maze Therapeutics is at the forefront of precision medicine, aiming to transform patient care through innovative approaches to drug discovery and development. We are dedicated to providing solutions that meet the specific needs of patients with both common and rare diseases.
Join Artech Information Systems LLC as an Associate Scientist II in Product Assurance, where you will play a pivotal role in ensuring the quality and reliability of our innovative products. You will collaborate with a dynamic team to perform testing and validation, contributing to the development of cutting-edge technologies.
Oric Pharmaceuticals is hiring a Director of IT Enterprise Applications to lead the company’s approach to enterprise software. This role sits within the Information Technology team and plays a key part in shaping how technology supports daily business operations. Key responsibilities Develop and carry out strategies for enterprise application systems. Oversee projects that implement new software in support of company-wide objectives. Collaborate with teams across departments to ensure technology solutions fit business needs. Promote both innovation and efficiency through the use of enterprise applications. Location This position is based in South San Francisco.
Full-time|$150K/yr - $240K/yr|On-site|South San Francisco, California, United States
About Xaira TherapeuticsXaira Therapeutics is a cutting-edge biotechnology startup dedicated to harnessing the power of artificial intelligence to revolutionize the fields of drug discovery and development. Our mission is to innovate generative AI models that facilitate the design of protein and antibody therapeutics, paving the way for effective treatments against traditionally challenging molecular targets. In addition, we are advancing foundational biological models to enhance target identification and patient stratification. These pioneering technologies are designed to continuously uncover novel therapies and boost the success rates in drug development. Our headquarters are strategically located in the San Francisco Bay Area, Seattle, and London.About the RoleWe are seeking an AI Scientist to become an integral part of our team at the convergence of machine learning and single-cell biology. In this pivotal role, you will focus on the development and application of foundational models to large-scale perturb-seq and single-cell datasets, revealing new biological mechanisms and therapeutic potentials. You will be responsible for designing scalable machine learning architectures that can extract insights from high-dimensional perturbation data and integrate across multi-omic modalities.
Join our dynamic team at Cellares as an Automation Engineer. In this pivotal role, you will be instrumental in designing, implementing, and enhancing cutting-edge lab automation systems. Your expertise will facilitate the development of scalable, efficient, and robust automated workflows for high-throughput quality control testing in cell therapy manufacturing.The ideal candidate will excel in developing and managing liquid handling techniques while also integrating both off-the-shelf instruments and customized hardware into a fully automated workcell. Collaboration with cross-functional teams is essential as you contribute to refining system designs and crafting strategies for workflow optimization. Additionally, you will lead the creation and evaluation of verification and validation plans for our automation systems.We are looking for individuals who thrive in a fast-paced, mission-oriented environment and are eager to engage with a wide array of challenges as our company continues to expand.
Full-time|$135K/yr - $180K/yr|Hybrid|South San Francisco, California, United States
Join the innovative team at Atomic AI, where we harness artificial intelligence to redefine drug discovery. Our pioneering R&D platform, recognized on the cover of Science, aims to tackle previously undruggable diseases by focusing on RNA. As we continually enhance this platform, we are developing cutting-edge machine learning methods and unique foundation models driven by extensive in-house experimental data. Our interdisciplinary team of scientists and engineers believes that our workforce is our greatest asset and vital to our success.The RoleAs a full-time Data Scientist on our Machine Learning team, you will collaborate with scientists and engineers to advance our RNA technology platform for RNA structure prediction, target identification, and early-stage drug discovery. You will spearhead the curation of RNA-centric datasets for machine learning training and validation, uncover statistical patterns in our extensive datasets regarding RNA structure and RNA-small molecule interactions, and devise innovative strategies to assess the accuracy of our machine learning models. Your insights will drive the refinement of our ML models and the strategic acquisition of new experimental data.This is a hybrid position requiring three days per week in our South San Francisco office.
Full-time|$175K/yr - $220K/yr|On-site|South San Francisco Lab
Innovative Minds Wanted Are you ready to achieve what others deem impossible? If the prospect excites you, keep reading!Since our inception in 2015, we have adopted a revolutionary “moneyball for biotech” strategy, uniting promising early-stage research from academia under a single financial umbrella to minimize risks and foster innovation. This unique approach empowers small teams of experts to drive scientific breakthroughs, particularly in rare diseases, delivering transformative medicines for patients with unmet medical needs as swiftly as possible. At BridgeBio, we venture into uncharted territories, challenge the status quo, and inspire individuals to tackle complex challenges. If you’re a trailblazer who thinks outside the box, we invite you to collaborate with some of the brightest minds in the biopharma industry. Together, let’s ask “why not?” and reshape the future of medicine, leveraging curiosity and innovative tools, including ethical AI, to enhance clarity, efficiency, and quality in our work. Your ProfileAs a Learning and Development Lead at BridgeBio, you will be a pivotal figure with a proven record in the biotech realm, particularly in rare disease training and development:Demonstrated expertise in understanding complex clinical information related to assigned products and disease statesProven ability to steer multifaceted projects, influence key stakeholders, and foster collaboration across various departmentsSkilled communicator in a dynamic and fast-paced environment Key Responsibilities: Senior Manager / Associate Director of TrainingYou will report to the Senior Director of Training and Learning Excellence, spearheading the design, development, implementation, and assessment of comprehensive training programs that support the launch of rare disease commercial products...
Contract|$168K/yr - $200K/yr|On-site|South San Francisco
At Alumis Inc., we are dedicated to revolutionizing the lives of patients suffering from autoimmune diseases through precision medicine. Despite recent treatment advancements, many individuals continue to endure challenges related to immunologic conditions. Our mission is to fundamentally improve patient outcomes.We are in search of a proactive and skilled leader to join our IT team as a Senior Manager, IT, R&D Applications (Contractor). In this pivotal role, you will support essential business applications that cater to the corporate needs of our Development and Research teams, including Quality Assurance, Clinical Operations, Biometrics, Medical Affairs, and Regulatory functions. Additionally, you will play a crucial role in enterprise-level initiatives. Working closely with various stakeholders, you will manage the implementation, maintenance, and ongoing support of SaaS technologies that enhance operational efficiency and drive business success. The ideal candidate should possess a robust technical background, demonstrate excellent organizational skills, work independently, and embody a positive, solution-oriented mindset. This position reports directly to the Director of R&D Business Partner.
Cellares is on the lookout for a dedicated Senior Electrical Engineer who is enthusiastic about electrical design and automation. This key role will play a crucial part in advancing our cutting-edge cell therapy manufacturing platform.Your primary focus will be on the electrical systems integrated within cell therapy manufacturing equipment. This includes the design, documentation, and validation of control panels, PCBAs, and interconnecting cabling. You will collaborate with various departments to develop innovative products that make a significant impact in the cell and gene therapy sector. This position offers an exciting opportunity for career growth under the guidance of a highly skilled, cross-functional engineering team.We are seeking candidates who thrive in a dynamic, mission-oriented environment and are ready to embrace a wide range of challenges as our company expands.
Full-time|$10K/yr - $15K/yr|On-site|South San Francisco, California, United States
About Xaira TherapeuticsXaira Therapeutics is a pioneering biotech startup dedicated to harnessing the power of artificial intelligence to revolutionize drug discovery and development. Our mission is to advance the frontier of generative AI models which design innovative protein and antibody therapeutics, making strides against previously difficult molecular targets. Additionally, we are committed to creating foundational models for biology and disease, enhancing target identification and patient stratification. Through these cutting-edge technologies, we aim to consistently unveil novel therapies and elevate the success rates in drug development. Headquartered in the dynamic San Francisco Bay Area, with additional offices in Seattle and London, we are at the forefront of biotech innovation.AI in ResidenceThe AI in Residence program is a highly selective opportunity designed for those at the forefront of machine learning and drug discovery. This role serves as an industry alternative to a traditional postdoctoral position, tailored for exceptional researchers and engineers eager to apply advanced AI methodologies to real-world biomedical challenges, encompassing the entire process from data handling to system deployment.As a resident, you will join a small, focused cohort engaged in high-impact AI projects throughout Xaira. You will closely collaborate with AI scientists, research engineers, and drug discovery teams to conceptualize, develop, and deliver machine learning capabilities that directly impact therapeutic programs. This role demands hands-on, system-level work with tangible scientific implications.We seek candidates who possess technical expertise, intellectual independence, robust research judgment, and a proven track record of high-quality deliverables, whether through publications, contributions to open-source projects, or production systems.
Are you unable to find a position that aligns perfectly with your skills and aspirations? Don't worry! We've created a general job application process that allows you to submit your resume and get noticed by our Recruiting Team.Please attach your resume and provide a cover letter, although it's not mandatory. A cover letter can help us understand your career goals and interests at Twist.Our Recruiting Team will evaluate your submission. Should a suitable position arise that matches your interests, we will reach out to you promptly. If not, we will keep your information on file for future opportunities. Twist Bioscience is expanding, and new roles are likely to open soon!Thank you for your interest in joining us!
Full-time|$140K/yr - $180K/yr|On-site|South San Francisco, California, USA
About You and The RoleThe Application Software team at Zipline is crucial in developing and maintaining the operating system for our innovative drone delivery service. We create and support essential applications that enhance design, manufacturing, maintenance, and service processes, ensuring that our tools evolve with the company's growing needs.We are in search of a dedicated Product Lifecycle Management (PLM) Systems Analyst to manage and support our suite of engineering tools, including Teamcenter, NX, StarCCM+, and other Siemens applications. In this pivotal role, you will ensure system reliability, manage configurations, oversee user administration, and provide operational support on a day-to-day basis. Responsibilities include addressing L1/L2 support tickets, collaborating with Siemens on escalations, maintaining documentation, and enhancing the user experience for our engineering and operations teams.We seek an intelligent, resourceful, proactive, and collaborative individual who thrives on solving challenges in a dynamic environment and is eager to contribute to impactful missions. You will take ownership of issues from start to finish, working closely with engineers, IT, and external vendors to ensure stability, security, and efficiency in our engineering systems. Your commitment to enhancing our experience with Siemens tools will contribute to system stability, expedite issue resolution, and minimize disruptions, allowing users to remain productive.What You’ll DoAdminister and support Teamcenter, NX, StarCCM+, and related Siemens engineering tools on a daily basisHandle L1 and L2 PLM support, including user access, troubleshooting, and system configuration issues, focusing on identifying and mitigating recurring problemsCollaborate with Siemens and internal IT to resolve escalated issues, monitor progress, and ensure timely resolutionsAssist with system configuration, environment management, and routine maintenance tasksDocument processes, troubleshooting steps, and system updates to create scalable and repeatable workflowsSupport system upgrades, patches, and release cycles, including testing, validation, and user coordination to minimize disruptions to engineering teamsWork directly with engineers to understand tool usage, identify gaps and challenges, and propose and implement improvements to enhance usability and reliabilityTroubleshoot integrations between Teamcenter and other engineering and enterprise systemsFacilitate onboarding for new users, including system access and tool training
Full-time|On-site|South San Francisco, California, USA
About ZiplineZipline stands as the foremost leader in drone delivery services globally, dedicated to ensuring equitable access to essential goods such as food, medicine, and supplies, anytime and anywhere. We engineer, manufacture, and execute the largest autonomous logistics network worldwide, facilitating prompt and dependable delivery of critical resources. Operating across four continents, we achieve a delivery approximately every 30 seconds, with millions of successful deliveries of blood, vaccines, and other vital products to date.Our clientele encompasses prominent healthcare systems, governments, retailers, and global enterprises who depend on us to save lives, minimize emissions, and foster economic growth through rapid delivery solutions. The drone technology is just a fraction of our comprehensive systems designed for seamless global operations.By optimizing supply chains and alleviating congestion, we are reclaiming valuable time for individuals. With over 140 million commercial autonomous miles flown safely, Zipline is redefining access to healthcare, consumer products, and food on a global scale.We operate on a global scale and seek innovative problem solvers eager to tackle real-world challenges in a rapidly growing environment. Our team is driven by a mission to create systems that make a tangible difference in people's lives while scaling the logistics of the future. We are looking for individuals who approach challenges from the ground up, thrive in adversity, and accomplish the seemingly impossible at unprecedented speeds.About ZiplineAre you ready to make a difference? Zipline is on a transformative journey to revolutionize the movement of goods. Our mission is to address urgent global access issues by developing a logistics system that provides instant delivery services for everyone, regardless of location.From powering Rwanda's national blood delivery network and managing Ghana's COVID-19 vaccine distribution to providing on-demand home delivery for Walmart and helping healthcare providers reach patients directly in the U.S., we are reshaping logistics for businesses, governments, and consumers.While our technology is sophisticated, our vision is straightforward: a teleportation service that delivers exactly what you need, when you need it. Through advanced robotics and autonomous systems, we are actively reducing delivery-related carbon emissions, road congestion, and fossil fuel reliance while ensuring equitable access for billions and strengthening the global supply chain.
Full-time|$105K/yr - $140K/yr|On-site|South San Francisco, California, USA
About ZiplineAre you ready to make a difference? At Zipline, we harness the power of drones to deliver essential and life-saving medicines to hospitals around the globe, impacting millions of lives. Our mission is to ensure that every individual on Earth has immediate access to crucial medical supplies. Join us at Zipline and be part of a transformative journey that can reach billions.About the RoleAs a Quality Manufacturing Engineer within our manufacturing quality team, you will play a pivotal role in ensuring that each vehicle produced meets Zipline’s stringent performance criteria. Your responsibilities will include managing inspection findings and non-conformances, leading investigations into root causes, and implementing corrective measures to enhance yield and production efficiency. You will outline and document inspection protocols, rework procedures, and provide feedback to suppliers, collaborating with cross-functional teams to address quality issues effectively.
Full-time|$170K/yr - $210K/yr|On-site|South San Francisco, California, USA
About ZiplineAre you ready to make a significant impact? Zipline is on a transformative mission to revolutionize logistics and delivery systems across the globe. We are dedicated to addressing the most pressing access challenges by developing the first instant delivery and logistics network that serves everyone equally, no matter where they are. From supporting Rwanda's national blood delivery system and Ghana's COVID-19 vaccine distribution to facilitating on-demand home deliveries for Walmart, we are changing how goods are transported for businesses, governments, and consumers alike.The technology we utilize is intricate, yet our goal is straightforward: to create a teleportation service that delivers essentials precisely when needed. Our robotics and autonomous systems are designed to reduce carbon emissions, alleviate road congestion, and minimize fossil fuel dependency while ensuring equitable access for billions of people and strengthening the global supply chain. Join Zipline and contribute to our vision of establishing a fair and robust global supply chain for billions worldwide.About You and The RoleAs a key member of Zipline’s Flight Controls team, you will play a pivotal role in modeling, developing, and testing critical flight software systems that empower our vehicles to deliver autonomously. Our team excels at innovating solutions that allow our delivery platforms to operate seamlessly in diverse and increasingly challenging environments, ensuring equitable service to all. You will leverage a variety of analytical techniques to assess system performance and understand how design decisions impact capabilities and requirements. Collaboration across teams will be essential as you drive enhancements to our products using data derived from flight testing and our extensive fleet of customer aircraft. By engaging closely with our customers, you will gather insights to identify improvements and prioritize our next growth phases. Your success directly influences the operational effectiveness of our logistics network.
Full-time|$122K/yr - $170K/yr|Remote|Remote ; San Diego, California, United States; South San Francisco, California, United States
Join Veracyte, a leader in transforming cancer care through innovative diagnostics that empower patients and clinicians alike. At Veracyte, we provide an inspiring work environment where you can make a significant impact on patients' lives while advancing your career. Our culture, known as the Veracyte way, emphasizes collaboration, resilience, and a commitment to excellence.Our Core Values:We Seek A Better Way: We boldly innovate and learn from challenges to improve cancer care.We Make It Happen: We prioritize urgency, quality, and enjoyment in our work.We Are Stronger Together: We foster open collaboration and celebrate our collective successes.We Care Deeply: We honor our diverse backgrounds and support each other in doing what is right.The Role:We are on the lookout for an enthusiastic Bioinformatics Research Scientist to join our Translational Bioinformatics group within the Bioinformatics and Data Science Team. This pivotal role involves leveraging computational and statistical techniques on extensive transcriptomic and genomic datasets, particularly focusing on prostate cancer biology and its clinical implications. The ideal candidate will play a key role in identifying clinically relevant molecular signatures that enhance disease stratification, prognosis, and the development of diagnostics, while effectively communicating findings to both scientific and clinical audiences. This position offers a unique opportunity to bridge the realms of data science, biology, and clinical research through close collaboration with scientists, clinicians, and cross-functional teams to convert complex data into actionable insights.
Full-time|$125K/yr - $170K/yr|On-site|South San Francisco, California, USA
About Zipline Are you ready to make a significant impact? Zipline is committed to revolutionizing the logistics landscape. Our mission is to tackle the world's most pressing access challenges by creating, manufacturing, and operating the first instant delivery and logistics system that caters to all individuals, regardless of their location. From powering Rwanda's national blood delivery network and facilitating Ghana's COVID-19 vaccine distribution to enabling Walmart's on-demand home delivery, we are reshaping the movement of goods for businesses, governments, and consumers alike. Our technology may be intricate, but our vision is straightforward: a teleportation service that delivers essential items promptly. Through our innovative use of robotics and autonomous systems, we are not only decarbonizing deliveries but also alleviating road congestion, reducing fossil fuel usage, and combating air pollution, all while ensuring equitable access for billions and strengthening the global supply chain. About You and The Role Are you excited by the challenge of developing large, integrated electro-mechanical systems—from initial engineering builds to full-scale production and worldwide deployment? Do you thrive on tackling tasks that others deem too difficult or impossible? Are you the engineer everyone turns to for insights on building and scaling unprecedented projects? At Zipline, our work has real-world implications. Families and patients depend on us daily, and there is no margin for error. If you are passionate about leveraging your engineering skills to devise efficient and innovative manufacturing solutions, we encourage you to continue reading. We are in search of a highly skilled and proactive Senior Manufacturing Engineer to join our team. In this pivotal role, you will be tasked with designing and scaling multiple in-house final assembly lines for our aircraft, zips, docks, and various essential feeder sub-assemblies. You will ensure these lines meet escalating demand—from tens of units weekly to hundreds over the next three years—while continuously reducing costs and enhancing product quality. If you excel in fast-paced environments, enjoy managing multiple new developments simultaneously, and can swiftly align teams towards solutions, we would love to connect with you.
Lightship is hiring a Senior Engineering Technician at its South San Francisco facility. This position plays a key part in supporting the design, development, and testing of engineering projects, working closely with engineers to guide ideas from concept to completion. A hands-on approach and technical know-how are essential for keeping projects on schedule and meeting goals. Key responsibilities Support engineering design, development, and testing tasks Collaborate with engineers to address technical challenges as they arise Contribute to maintaining quality and performance standards throughout project phases What we look for Proactive approach and strong problem-solving abilities Genuine enthusiasm for engineering and technology Background in supporting engineering projects from initial stages through completion
Full-time|$130K/yr - $165K/yr|On-site|South San Francisco, California, USA
ABOUT ZIPLINEAre you ready to make a difference? At Zipline, we are revolutionizing the logistics of goods transportation. Our mission is to address the world's most pressing access challenges by creating, manufacturing, and operating an instant delivery system that serves all people, regardless of their location. From supporting Rwanda’s national blood delivery network and distributing COVID-19 vaccines in Ghana to facilitating on-demand delivery for Walmart and enabling healthcare providers to reach patients' homes across the U.S., we are reshaping logistics for businesses, governments, and consumers alike. Our technology blends robotics and autonomy to decarbonize delivery systems, alleviate traffic congestion, reduce fossil fuel dependency, and ensure equitable access for billions while reinforcing a more resilient global supply chain.Join us at Zipline and contribute to our vision of building a fair and robust global supply chain that benefits everyone.ABOUT YOU AND THE ROLEThe Avionics team comprises skilled hardware, software, and testing experts dedicated to designing resilient systems that power our life-saving drone delivery operations in some of the most challenging environments worldwide. We are tasked with creating aircraft avionics capable of performing optimally in diverse and harsh climatic and electromagnetic interference (EMI) conditions. As a crucial component of the overall Zipline aircraft system architecture, we prioritize high performance and reliability while minimizing weight and costs.In this role, you will collaborate with our team to deliver high-performance flight computers and tightly integrated communication and navigation systems. These avionics systems are central to our new unmanned aerial system, which aims to scale Zipline’s deliveries from 100,000 to 100 million per year globally. The success of Zipline hinges on developing avionics systems that are lightweight, cost-effective, reliable, and capable of high-volume production. This position requires rigorous engineering design and validation efforts, alongside innovative approaches to packaging, integration, fault tolerance, and validation. We seek a test engineer with a solid background in electrical engineering principles and relevant experience in manufacturing testing, design validation, system performance characterization, and certification.
Full-time|On-site|South San Francisco, California, USA
Join FlyZipline as a Senior Staff RF Test Engineer and play a pivotal role in revolutionizing the logistics industry through cutting-edge drone technology. In this position, you will be responsible for designing, implementing, and executing tests to validate RF components, ensuring our systems meet the highest standards of reliability and performance.This role requires a strategic thinker with a passion for innovation and a commitment to excellence in engineering practices. You will collaborate with cross-functional teams to enhance our product offerings and contribute to our mission of delivering essential medical supplies swiftly and efficiently.
Full-time|$150K/yr - $150K/yr|On-site|South San Francisco, California, USA
ROLE EXPECTATIONS Zipline is seeking innovative software engineers to create the essential tools and infrastructure that support our systems validation and flight testing departments. This dynamic team is responsible for developing accurate, efficient, and scalable software solutions to validate both aircraft and ground systems across various levels. Our projects range from integrating real avionics, sensors, actuators, and radios with high-fidelity simulated environments in bench-top Hardware-in-the-Loop (HIL) configurations to building applications that plan, orchestrate, and assess thousands of automated and non-standard real-world flight tests on a daily basis. Your contributions will significantly enhance the speed, confidence, and quality of hardware and software development at Zipline. In this position, you will gain in-depth knowledge of Zipline’s comprehensive logistics system and collaborate closely with cross-functional partners who depend on your tools to deliver reliable, flight-ready software. Most critically, the systems you develop will act as the final safeguard before software and hardware are deployed globally for crucial real-world deliveries.
