Senior Staff / Principal Engineer - Digital Ecosystem

At GRAIL, we are committed to revolutionizing cancer care by enabling early detection when it is most treatable. Our innovative approach combines cutting-edge technology, including next-generation sequencing (NGS), with extensive clinical studies to address one of the most significant challenges in healthcare.We pride ourselves on our diverse, multidisciplinary team of scientists, engineers, and healthcare professionals who collaborate to develop solutions that enhance patient outcomes. With headquarters in the Bay Area and additional offices in Washington, D.C., North Carolina, and the UK, we are supported by top-tier global investors and industry leaders.As a Staff Quality Process Engineer, you will be a pivotal technical leader responsible for driving quality process engineering initiatives that comply with internal protocols, meet customer standards, and adhere to regulatory mandates. Your expertise will help tackle intricate quality issues, spearhead cross-functional projects, and foster a culture of continuous improvement, ultimately contributing to product reliability and operational excellence.This position is based in our Durham, North Carolina office, offering a flexible work arrangement. Employees are expected to work at least 60% of their hours on-site, with specific schedules determined collaboratively with supervisors to align with team and operational requirements.

At GRAIL, we are on a groundbreaking mission to revolutionize cancer detection, focusing on early diagnosis when the disease is most treatable. Our goal is to change the trajectory of cancer mortality by uniting diverse stakeholders to embrace innovative, safe, and effective technologies that can transform the landscape of cancer care.As a pioneering healthcare company, we are at the forefront of developing advanced technologies aimed at enhancing early cancer detection. Our multidisciplinary team comprises talented scientists, engineers, and physicians leveraging next-generation sequencing (NGS), large-scale clinical studies, and cutting-edge computer and data science to tackle one of medicine’s most formidable challenges.With headquarters in the Bay Area and additional locations in Washington, D.C., North Carolina, and the United Kingdom, GRAIL is supported by prominent global investors, as well as leading pharmaceutical, technology, and healthcare organizations.For more details about our mission and innovations, please visit grail.comWe are currently seeking a Senior Software Engineer to join our Data Solutions Team. This dynamic team is responsible for designing, building, and maintaining the robust software systems that oversee GRAIL’s comprehensive data lifecycle—from sample ingestion to downstream analysis—while adhering to stringent clinical, regulatory, and privacy standards. Your contributions will be pivotal in supporting clinical research, operations, and decision-making processes in our ongoing battle against cancer.In this role, you will assume technical ownership of systems that generate reliable, analysis-ready datasets utilized across GRAIL’s research and clinical initiatives. This is a software engineering position focused on developing complex production-grade systems that operate within dynamic, regulated environments, rather than merely assembling off-the-shelf ETL tools or crafting SQL-heavy pipelines. This position offers a high degree of autonomy and the opportunity to make a significant impact. You will work closely with research, clinical lab operations, and scientific teams, leading efforts to enhance our approach to structuring, validating, and delivering essential scientific and clinical data.This is a hybrid position based in either Menlo Park, CA (transitioning to Sunnyvale, CA in Fall 2026) or Durham, NC. Our current hybrid work policy requires on-site presence at least 60% of the time, including key in-person collaboration days.

We are seeking a dedicated and detail-oriented Quality Control Associate II to join our dynamic team. In this role, you will play a vital part in ensuring the highest standards of quality and safety in our products. You will be responsible for conducting thorough inspections, testing, and analysis to identify any potential quality issues and implement solutions promptly.

About the Role RR Donnelley is hiring a Quality Inspector II in Durham. This position focuses on inspecting products and processes to confirm they meet established quality standards. Careful review and a steady commitment to accuracy are essential in this work. What You Will Do Examine products and production steps for compliance with quality requirements Identify and report any defects or deviations from specifications Support the team’s efforts to deliver reliable service to clients What We Value Strong attention to detail Consistent approach to quality and process Dedication to upholding company standards

DLH Corporation is seeking a highly motivated and experienced Director of Program Management to lead and oversee our program management initiatives. The ideal candidate will possess a strong background in program management, excellent leadership skills, and a proven track record of successfully delivering complex projects on time and within budget. This role requires strategic thinking, effective communication, and the ability to collaborate with cross-functional teams.

Join Integrated Resources Inc. as a Quality Control Associate I, where you will play a pivotal role in ensuring the quality and integrity of our products. This entry-level position is perfect for individuals looking to start their career in quality control, with opportunities for growth and professional development.

As a Quality Assurance Manager at RR Donnelley, you will play a pivotal role in ensuring our products meet the highest standards of quality and reliability. Your expertise will guide our production and manufacturing processes, fostering a culture of excellence and compliance.

Join Areté Technologies Inc. as a Program Manager where you will have the opportunity to lead and manage critical projects that drive innovation and efficiency across our organization. In this role, you will collaborate with cross-functional teams, ensuring that projects are completed on time, within scope, and within budget. Your leadership will be key in developing project plans, managing resources, and communicating effectively with stakeholders.

We are seeking a dedicated and detail-oriented Validation Engineer to join our dynamic team. In this role, you will ensure the quality and compliance of our products through rigorous validation processes. You will work closely with cross-functional teams to establish validation protocols, execute test plans, and analyze results to drive continuous improvement.

At GRAIL, we are on a vital mission to revolutionize cancer detection, striving to identify the disease in its earliest stages when it is most treatable. Our innovative approach aims to alter the course of cancer mortality, fostering collaboration among stakeholders to embrace groundbreaking, safe, and effective technologies that will reshape cancer care.As a pioneering healthcare company, GRAIL is at the forefront of advancing early cancer detection through state-of-the-art technologies. Our dynamic team comprises scientists, engineers, and healthcare professionals who leverage next-generation sequencing (NGS), large-scale clinical studies, and cutting-edge data science to tackle one of healthcare’s toughest challenges.With headquarters in the Bay Area, California, GRAIL also has offices in Washington, D.C., North Carolina, and the United Kingdom, backed by prominent global investors and leaders in the pharmaceutical, technology, and healthcare sectors.For more details, please visit grail.com.The Associate Director of Quality Processes will provide both strategic vision and operational leadership within our quality function. This role is pivotal in ensuring our products, processes, and systems uphold the highest standards of compliance, reliability, and customer satisfaction. Responsibilities include defining and executing quality system strategies, leading cross-functional initiatives, and managing quality operations across various teams and locations. As a key leader, you will cultivate a culture of quality, drive continuous improvement efforts, and prepare the organization for regulatory and customer audits.This position is located at our Durham, North Carolina office, offering a flexible work arrangement that allows for both in-office and remote work. Current policy requires a minimum of 60% of your workweek, or 24 hours, to be on-site, with specific schedules determined collaboratively with your manager based on team and business requirements.

About UsDLH Corporation is dedicated to enhancing health and national security readiness through innovative solutions in scientific research, systems engineering, and digital transformation. Our team of experts in public health and operational performance works tirelessly to address the complex challenges faced by both civilian and military sectors. By leveraging cutting-edge tools such as artificial intelligence, data analytics, and cloud technologies, we strive to improve the lives of millions. With a workforce of over 2,400 professionals committed to the principle that 'Your Mission is Our Passion,' DLH combines extensive government sector experience with proven methodologies and a steadfast commitment to innovation. OverviewDLH is actively seeking a visionary Project Director to lead a significant federally funded cohort study focused on understanding environmental and genetic risk factors for cancer and other chronic diseases. The Project Director will be responsible for comprehensive contract execution, leading multidisciplinary teams, and collaborating with government Principal Investigators. This role encompasses overseeing complex, protocol-driven research activities, including participant engagement, biospecimen management, data operations, and outcome validation. The ideal candidate will possess a balance of executive project management skills and epidemiologic expertise, driving strategic study initiatives and operational excellence throughout all research phases. Additionally, the Project Director should have a well-established professional network and the strategic insight to identify and secure new contract opportunities that broaden our public health research endeavors.

Role Overview Grail Bio is hiring a Quality Systems Training Manager in Durham, NC. This position focuses on building and maintaining training programs that uphold quality standards throughout the company. The manager will shape and oversee training efforts that support compliance and encourage a strong quality culture across teams.

Join our team as an EHR Program Manager in Durham, NC. We are seeking a dynamic professional with a passion for healthcare technology and a strong background in Electronic Health Records (EHR) management. In this role, you will be responsible for overseeing the implementation, optimization, and ongoing management of EHR systems to improve patient care and operational efficiency.As an EHR Program Manager, you will collaborate with cross-functional teams, engage with healthcare providers, and monitor project milestones to ensure timely delivery of EHR initiatives. Your expertise will be crucial in driving process improvements and enhancing user adoption of EHR systems.

At GRAIL, our mission is to revolutionize cancer care by detecting cancer at its earliest and most treatable stages. We are committed to altering the landscape of cancer mortality through innovative technologies that foster collaboration among diverse stakeholders in healthcare.As a leader in the healthcare space, GRAIL is at the forefront of developing groundbreaking technologies that enhance early cancer detection. Our multidisciplinary team comprises top-tier scientists, engineers, and medical professionals who leverage next-generation sequencing (NGS), extensive clinical studies, and cutting-edge data science to tackle one of the most significant challenges in modern medicine.Headquartered in the Bay Area of California, GRAIL also has offices in Washington, D.C., North Carolina, and the United Kingdom, backed by prominent global investors and partnerships within the pharmaceutical, technology, and healthcare sectors.For more information, please visit grail.com.We are seeking a dedicated Quality Audit Specialist II to join our team. This role involves supporting the development, execution, and upkeep of our internal audit program, as well as assisting with various Quality Management Systems (QMS) initiatives as necessary.This position is located at our Durham, North Carolina office, offering a flexible work arrangement that allows you to work both on-site and remotely. Our current policy stipulates that a minimum of 60% (or 24 hours) of your workweek must be performed on-site, with your specific schedule determined in collaboration with your manager to meet both team and business needs.

We are seeking an enthusiastic and dedicated HR & People Programs Partner to join our dynamic team at Grailbio. This role is pivotal in fostering a positive workplace culture and enhancing our employee experience. As a partner in our HR initiatives, you will work collaboratively across departments to implement effective HR programs and support our strategic goals.Key responsibilities will include developing and managing HR policies, facilitating training programs, and leading employee engagement activities. Your expertise will help us attract and retain top talent, ensuring that Grailbio remains a great place to work.

Flatiron Health is working to improve cancer care through data and technology. The Durham office is looking for a Senior Research Scientist to join the Statistical Programming team. This group develops analytic tools and insights that help clinicians, researchers, and patients. Role Overview This position focuses on statistical programming using R, with an emphasis on real-world evidence in oncology. The Senior Research Scientist will contribute expertise to multiple research projects and help shape Flatiron’s approach to cancer data analysis. What You Will Do Lead statistical programming for several research projects at once, ensuring quality and consistency. Advise on complex epidemiological and statistical methods, study design, data limitations, and modeling approaches for the programming team. Translate statistical analysis plans into R code independently, building analytic datasets and producing both descriptive and inferential statistics. Collaborate with principal investigators to create data visualizations, sometimes using innovative variables or advanced statistical methods. Serve as a subject matter expert on Flatiron’s data sources, including EHR-derived real-world data, clinico-genomics, machine learning-extracted data, and claims data. Apply knowledge of cancer biology, therapy, or epidemiology across major tumor types to provide scientific and analytic guidance. Mentor and support other statistical programming staff. Partner with cross-functional teams to deliver client-sponsored research studies on time. Lead projects to improve Flatiron’s proprietary analytical tools. Who You Are This role suits someone who collaborates well and enjoys solving problems with a team. Strong analytical skills and clear communication are essential. Experience working with real-world data, such as healthcare claims or electronic health records, is important. Curiosity and a willingness to take on meaningful challenges each day are valued here.

Athletes Unlimited, recognized as one of Sports Business Journal's Best Places to Work in Sports (2024, 2025), Front Office Sports' Most Impactful Sports Organizations (2024), and Fast Company’s Most Innovative Companies (2023), is a pioneering organization that operates professional women's softball, volleyball, and basketball leagues, offering unparalleled competition and fan engagement. Our unique model emphasizes athlete representation and profit-sharing, ensuring that players actively participate in shaping the policies that support them. As the first professional sports league organized as a Public Benefit Corporation, we are committed to prioritizing the interests of athletes.In June 2025, AU launched the Athletes Unlimited Softball League (AUSL), a premier professional women's softball league that has expanded to include additional teams and a city-based model, enhancing opportunities for engagement with fans and partners.The AUSL is currently seeking dedicated individuals to assist with day-to-day operations and event management for the Durham Blaze. Ideal candidates should possess a solid understanding of softball, be physically capable of performing various tasks, and demonstrate a commitment to supporting a professional women's softball team. Applicants must reside in the Durham area and have reliable transportation.Important Dates:June - July: Approximately 9 days of setup/teardown, 2 practice days, and 3 games per week. This role revolves around the AUSL Regular Season Schedule, including practices and game days, with additional hours dedicated to pre- and post-game operations.

Join our dynamic team at 360itprofessionals1 as a Mid-Level Quality Assurance Analyst. We are seeking a talented individual with experience in QTP (QuickTest Professional) and HP QC (Quality Center) to ensure the highest quality standards in our software development processes. As part of our team, you will be responsible for creating and executing test cases, identifying defects, and collaborating with developers to enhance product quality.

Join our dynamic team at 360IT Professionals as a Mid-Level Quality Assurance Tester. We are looking for an individual with hands-on experience in QTP and HP Quality Center (QC) to ensure the highest quality of our software products. This role is crucial in identifying and resolving defects in our applications through comprehensive testing strategies.As a Quality Assurance Tester, you will collaborate closely with developers and project managers to develop test plans, execute test cases, and document test results. Your expertise will help drive improvements in our development processes and enhance product quality.